GW280264X是一种金属蛋白酶 ADAM10 和 ADAM17 的有效抑制剂,IC50 分别为 8.0 nM 和 11.5 nM。该化合物能够调节免疫原性,尤其在胶质母细胞瘤起始细胞中的研究中具有应用潜力,适用于癌症及免疫治疗相关的研究。
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
规格 | 价格 | 会员价 | 库存 | 数量 | |||
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快速发货 顺丰冷链运输,1-2 天到达
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免费溶解
产品名称 | MMP ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Marimastat |
+++
MMP-7, IC50: 16 nM MMP-14, IC50: 3 nM |
98% | |||||||||||||||||
Ilomastat |
++++
MMP-26, Ki: 0.36 nM MMP-2, Ki: 0.1 nM |
99%+ | |||||||||||||||||
SB-3CT |
+
MMP-2, Ki: 13.9 nM MMP-9, Ki: 600 nM |
99%+ | |||||||||||||||||
Doxycycline | ✔ | 98% | |||||||||||||||||
Batimastat |
+++
MMP-7, IC50: 4 nM MMP-1, IC50: 3 nM |
99%+ | |||||||||||||||||
Nobiletin | ✔ | 98% | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | GW280264X is an inhibitor of ADAM10/17 with IC50s of 11.5 nM and 8.0 nM, respectively[1].At a concentration of 3 µM, acting for 48 hours, GW280264X inhibited GS-7 cell proliferation[2]. |
Animal study | Administered intraperitoneally at a dose of 100 µg/kg once daily for one week starting 4 hours after surgery, GW280264X significantly improved functional recovery after spinal cord injury in an animal model[3]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.74mL 0.35mL 0.17mL |
8.68mL 1.74mL 0.87mL |
17.37mL 3.47mL 1.74mL |
CAS号 | 866924-39-2 |
分子式 | C28H41N5O6S |
分子量 | 575.72 |
别名 | |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Sealed in dry,Store in freezer, under -20°C |
溶解度 |
DMSO: 120 mg/mL(208.43 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |