刺芒柄花素 /Formononetin
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货号：A204811
同义名：
Biochanin B;Flavosil
Formononetin 可作为芳香烃受体的激动剂（EC50 = 130 nM），具有预防乳腺癌、前列腺癌和结肠癌的作用。Formononetin 可以从 Ononis natrix L. 的树皮中提取。
Formononetin 化学结构
Formononetin 3D分子结构
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Formononetin 纯度/质量文件 产品仅供科研
货号：A204811
标准纯度：
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Formononetin 质控信息
StemRegenin 1
++
Aryl hydrocarbon receptor (AhR), IC50: 127 nM
99%+
CH-223191
+++
99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Formononetin 生物活性
描述
Formononetin is the main compound of red clover plants, which belongs to herbal isoflavone. in vivo , formononetin could reduce the nephrotoxicity by decreasing the accumulation of cisplatin in renal tubular cells. After formononetin treatment (15, 50, 75 mg/kg), the levels of BUN(blood urea nitrogen) and creatinine were decreased in a dose-dependent manner. The mRNA level of Kim-1 in the kidneys was significantly elevated at 48 h[3] [4]
Formononetin 临床研究
NCT号
适应症或疾病
临床期
招募状态
预计完成时间
地点
NCT02174666
Osteopenia
Os... 展开 >> teoporosis 收起 <<
Not Applicable
Unknown
September 2016
Denmark
... 展开 >> Aarhus University Hospital
Aarhus, Central Jutland Region, Denmark, 8000 收起 <<
NCT01497977
Low Serum Lipid Levels
Phase 4
Completed
-
Serbia
... 展开 >> Ultramedica Clinic, American Medical Academy
Belgrade, Serbia, 11000 收起 <<
Formononetin 参考文献
[1] Zhang X, Bi L, et al. Formononetin induces apoptosis in PC-3 prostate cancer cells through enhancing the Bax/Bcl-2 ratios and regulating the p38/Akt pathway. Nutr Cancer. 2014;66(4):656-61.
[2] Chen J, Zeng J, et al. Formononetin induces cell cycle arrest of human breast cancer cells via IGF1/PI3K/Akt pathways in vitro and in vivo. Horm Metab Res. 2011 Sep;43(10):681-6.
[3] Huang D, Wang C, Duan Y, Meng Q, Liu Z, Huo X, Sun H, Ma X, Liu K. Targeting Oct2 and P53: Formononetin prevents cisplatin-induced acute kidney injury. Toxicol Appl Pharmacol. 2017 Jul 1;326:15-24. doi: 10.1016/j.taap.2017.04.013. Epub 2017 Apr 13. Erratum in: Toxicol Appl Pharmacol. 2022 Sep 1;450:116133. PMID: 28414026.
[4] El-Bakoush A, Olajide OA. Formononetin inhibits neuroinflammation and increases estrogen receptor beta (ERβ) protein expression in BV2 microglia. Int Immunopharmacol. 2018 Aug;61:325-337. doi: 10.1016/j.intimp.2018.06.016. Epub 2018 Jun 15. PMID: 29913427.
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Formononetin 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
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1mg
5mg
10mg
1 mM
5 mM
10 mM
3.73mL
0.75mL
0.37mL
18.64mL
3.73mL
1.86mL
37.28mL
7.46mL
3.73mL
Formononetin 技术信息
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