There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
FM19G11 is a hypoxia-inducible factor-1-alpha (HIF-1α) inhibitor, suppresses hypoxia-induced luciferase activity with an IC50 of 80 nM in HeLa cells. It also influences other signaling pathways, including mTOR and PI3K/Akt/eNOS, when the HIF-1α pathway is inactive under normoxic conditions[1].[2].
体内研究
Through intramedullary injection over 1-8 weeks, FM19G11 improves locomotion in severe spinal cord injury (SCI)[3].
After 8 weeks of intramedullary injection, FM19G11 induces the expression of GAP43, an axon growth marker, and RIP, a marker for myelinated oligodendrocytes, at the injury site[3].
体外研究
In HeLa cell lines, FM19G11 at concentrations ranging from 30-300 nM inhibits HIFα proteins. Under hypoxic conditions, FM19G11 at 500 nM promotes oligodendrocyte differentiation[1].
Administered at 300 nM for 3 days, FM19G11 significantly reduces the mRNA levels of O6-methylguanine DNA-methyltransferase (MGMT) in hypoxic GBM‐XD, hypoxic T98G, and normoxic T98G cells[2].
FM19G11, when combined with temozolomide (TMZ), significantly enhances the pro‐apoptotic effect of TMZ, although FM19G11 alone does not induce apoptosis[2].
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