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FM19G11

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Chemical Structure| 329932-55-0 同义名 : -
CAS号 : 329932-55-0
货号 : A1154544
分子式 : C23H17N3O8
纯度 : 97%
分子量 : 463.396
MDL号 : MFCD01174289
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(226.59 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 FM19G11 is a hypoxia-inducible factor-1-alpha (HIF-1α) inhibitor, suppresses hypoxia-induced luciferase activity with an IC50 of 80 nM in HeLa cells. It also influences other signaling pathways, including mTOR and PI3K/Akt/eNOS, when the HIF-1α pathway is inactive under normoxic conditions[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.16mL

0.43mL

0.22mL

10.79mL

2.16mL

1.08mL

21.58mL

4.32mL

2.16mL
参考文献

[1]Victoria MM, et, al. FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status. J Biol Chem. 2010 Jan 8; 285(2): 1333-42.

[2]You CG, et, al. FM19G11 inhibits O 6 -methylguanine DNA-methyltransferase expression under both hypoxic and normoxic conditions. Cancer Med. 2018 May 15; 7(7): 3292-3300.

[3]Ana AA, et, al. FM19G11 and Ependymal Progenitor/Stem Cell Combinatory Treatment Enhances Neuronal Preservation and Oligodendrogenesis after Severe Spinal Cord Injury. Int J Mol Sci. 2018 Jan 9; 19(1): 200.