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首页 / 抑制剂/激动剂 / 膜转运蛋白 / ATPase / FCCP

碳酰氰 4-(三氟甲氧基)苯腙 /FCCP {[allProObj[0].p_purity_real_show]}

货号：A194814 同义名： Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone;Trifluoromethoxy carbonylcyanide phenylhydrazone

FCCP is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes.

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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
FCCP 化学结构 CAS号：370-86-5
FCCP 化学结构
CAS号：370-86-5
FCCP 3D分子结构
CAS号：370-86-5
FCCP 化学结构 CAS号：370-86-5
FCCP 3D分子结构 CAS号：370-86-5
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FCCP 纯度/质量文件 产品仅供科研

货号：A194814 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 ATPase ↓ 其他靶点 纯度
(-)-Blebbistatin 99%+
PF 03716556 ++++

H+/K+-ATPase, pIC50: ~6.5

 		98%
Esomeprazole sodium ✔ 98%
BTB06584 ✔ 98%
Ciclopirox ✔ 97%
CB-5083 ++++

p97 AAA ATPase, IC50: 11 nM

 		99%+
Ciclopirox olamine ✔ 99%
Brefeldin A +++

ATPase (HCT 116), IC50: 0.2 μM

 		99%+
Oligomycin A ✔ 99%
Sodium orthovanadate +++

(Na,K)-ATPase, IC50: 40 nM

 		99%
Golgicide A ✔ 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

FCCP 生物活性

描述 FCCP is a potent mitochondrial oxidative phosphorylation uncoupler which exhibits uncoupling effects at concentrations down to 10 -8 molar in mouse liver mitochondria[1]. Treatment with 5μM FCCP led to a reduction of ATP levels and ROS production and stimulated mitochondrial biogenesis related genes including Pgc-1α, mitochondrial genes such as Tfam and COXIV in hepatic stellate cells[2]. FCCP at concentration of 62.5nM and 125nM significantly reduced the mitochondrial membrane potential in the cytoplasmic and cortical region, as well as decreased ATP level of 8-cell embryos[3]. The processing of mutant APP in K695sw cells and wild-type APP in K695 cells was inhibited post treatment with 5μM FCCP for 4h[4].
作用机制 FCCP is a protonophore which can induce ionic currents carried by Na+ and H+ and depolarization dependent on the plasmalemmal proton gradient.[5]

FCCP 细胞研究

细胞系 浓度 检测类型 检测时间 活动说明 数据源
Hep3B cells 10 μM Function assay Stimulation of state 4 cellular respiration in human Hep3B cells at 10 uM in presence of oligomycin 22938093
MDA-MB-231 cells 1 uM Cytotoxicity assay Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation/viability at 1 uM 23245650
SH-SY5Y cells 10 μM Function assay 10 mins Induction of mitochondrial membrane potential loss in human SH-SY5Y cells at 10 uM incubated for 10 mins in presence of 0.2 uM CsA by TMRE dye based assay 25265024
T47D cells Function assay Inhibition of 1, 10-phenanthroline-induced HIF1 activation in human T47D cells by HRE3-TK-luciferase reporter gene assay, IC50=0.31 μM 20929261

FCCP 动物研究

Dose Rat: 0.5 mg/kg - 5 mg/kg[6] (i.p.); 1.5 mg/kg - 2.5 mg/kg[7] (s.c.)
Administration i.p., s.c.

FCCP 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00613860 Emphysema COP... 展开 >>D 收起 << Phase 3 Unknown December 2011 Germany ... 展开 >> Charite, University of Berlin Recruiting Berlin, Germany, 10117 Contact: Christian Witt, MD, PhD    +49 (030) 450 565 022    pneumologie@charite.de    Contact: Bernd Schmitt, MD    +49 (030) 450 565 02    pneumologie@charite.de    Thoraxklinik, University of Heidelberg Recruiting Heidelberg, Germany, 69190 Principal Investigator: Felix JF Herth, MD, PhD          Medical Center Nürnberg Recruiting Nürnberg, Germany, 90340 Contact: Joachim Ficker, MD, PHD    +49 (911) 398-2675    ficker@klinikum-nuernberg.de    Contact: Manfred Wagner, MD    +49 (911) 398-0    Manfred.Wagner@klinikum-nuernberg.de 收起 <<
NCT00176540 Fatigue Unspe... 展开 >>cified Adult Solid Tumor, Protocol Specific Unspecified Childhood Solid Tumor, Protocol Specific 收起 << Not Applicable Terminated(slow accrual) - United States, New Jersey ... 展开 >> Cancer Institute of New Jersey at Hamilton Hamilton, New Jersey, United States, 08690 Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School New Brunswick, New Jersey, United States, 08903 收起 <<
NCT01187147 Asthma Not Applicable Completed - Hong Kong ... 展开 >> University of Hong Kong Queen Mary Hospital Hong Kong, Hong Kong, 0 收起 <<

FCCP 参考文献

[1]HEYTLER PG, PRICHARD WW, et al. A new class of uncoupling agents--carbonyl cyanide phenylhydrazones. Biochem Biophys Res Commun. 1962 May 4;7:272-5.

[2]Guimarães EL, Best J, et al. Mitochondrial uncouplers inhibit hepatic stellate cell activation. BMC Gastroenterol. 2012 Jun 11;12:68.

[3]Zander-Fox DL, Fullston T, et al. Reduction of Mitochondrial Function by FCCP During Mouse Cleavage Stage Embryo Culture Reduces Birth Weight and Impairs the Metabolic Health of Offspring. Biol Reprod. 2015 May;92(5):124.

[4]Connop BP, Thies RL, et al. Novel effects of FCCP [carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone] on amyloid precursor protein processing. J Neurochem. 1999 Apr;72(4):1457-65.

[5]Park KS, Jo I, et al. FCCP depolarizes plasma membrane potential by activating proton and Na+ currents in bovine aortic endothelial cells. Pflugers Arch. 2002 Jan;443(3):344-52. Epub 2001 Oct 6.

FCCP 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.93mL

0.79mL

0.39mL

19.67mL

3.93mL

1.97mL

39.34mL

7.87mL

3.93mL

FCCP 技术信息

CAS号370-86-5
分子式C10H5F3N4O
分子量 254.168
别名 Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone;Trifluoromethoxy carbonylcyanide phenylhydrazone;para-Trifluoromethoxyphenylhydrazone, Carbonyl Cyanide.;p-Trifluoromethoxyphenylhydrazone, Carbonyl Cyanide;Carbonyl Cyanide para Trifluoromethoxyphenylhydrazone;Carbonyl cyanide-p-trifluoromethoxyphenylhydrazone
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature
溶解度

DMSO: 105 mg/mL(413.11 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 30 mg/mL(118.03 mM)，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方

IP 2% DMSO+2% Tween80+40% PEG300+water 3 mg/mL clear

PO 0.5% CMC-Na 36 mg/mL suspension

Tags: FCCP | 370-86-5 | Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone | Mitochondrial Metabolism | Metabolic Enzyme/Protease | Mitochondrial Metabolism | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | FCCP 纯度/质量文件 | FCCP 亚型比较 | FCCP 生物活性 | FCCP 细胞研究 | FCCP 动物研究 | FCCP 临床数据 | FCCP 参考文献 | FCCP 实验方案 | FCCP 技术信息

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