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炔雌醇 /Ethynylestradiol {[allProObj[0].p_purity_real_show]}

货号:A638512 同义名: 乙炔基雌二醇 / 17α-Ethynylestradiol;Ethinylestradiol

Ethynyl Estradiol is an estrogen used in formulations of combined contraceptive pills.

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Ethynylestradiol 化学结构 CAS号:57-63-6
Ethynylestradiol 化学结构
CAS号:57-63-6
Ethynylestradiol 3D分子结构
CAS号:57-63-6
Ethynylestradiol 化学结构 CAS号:57-63-6
Ethynylestradiol 3D分子结构 CAS号:57-63-6
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Ethynylestradiol 纯度/质量文件 产品仅供科研

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Ethynylestradiol 生物活性

描述 Ethinyl estradiol, also called 17α-Ethynyl estradiol, is contained in many oral contraceptives. The estradiol and progestin included in oral contraceptives prevent pregnancy by inhibiting the release of luteinizing hormone and follicle stimulating hormone from the pituitary gland, which prevents ovulation, changes the lining of the uterus to inhibit implantation, and alters the cervical mucus to prevent sperm from entering[3]. Neonatal exposure to Ethinyl estradio (low: 20 and high: 2000 g/kg) induced an abnormal estrous cycle during postnatal day 171–190 in low-dose group and postnatal day 126–145 in high-dose group[4]. Ethinyl estradiol at the dose of 5.0 μg/rat induced a decline in immobility behavior (p < 0.001) and an increase in both swimming (p < 0.04) and climbing (p < 0.001) behaviors compared with the control group[5].

Ethynylestradiol 参考文献

[1]Chen J, Delannoy M, et al. Enhanced mitochondrial gene transcript, ATP, bcl-2 protein levels, and altered glutathione distribution in ethinyl estradiol-treated cultured female rat hepatocytes. Toxicol Sci. 2003 Oct;75(2):271-8.

[2]Chen J, Li Y, et al. Increased mitochondrial superoxide production in rat liver mitochondria, rat hepatocytes, and HepG2 cells following ethinyl estradiol treatment. Toxicol Sci. 1999 Oct;51(2):224-35.

[3]Beltz AM, Hampson E, Berenbaum SA. Oral contraceptives and cognition: A role for ethinyl estradiol. Horm Behav. 2015 Aug;74:209-17. doi: 10.1016/j.yhbeh.2015.06.012. Epub 2015 Jun 27. PMID: 26122296.

[4]Nozawa K, Nagaoka K, Zhang H, Usuda K, Okazaki S, Taya K, Yoshida M, Watanabe G. Neonatal exposure to 17α-ethynyl estradiol affects ovarian gene expression and disrupts reproductive cycles in female rats. Reprod Toxicol. 2014 Jul;46:77-84. doi: 10.1016/j.reprotox.2014.03.001. Epub 2014 Mar 13. PMID: 24632129.

[5]Vega-Rivera NM, López-Rubalcava C, Estrada-Camarena E. The antidepressant-like effect of ethynyl estradiol is mediated by both serotonergic and noradrenergic systems in the forced swimming test. Neuroscience. 2013 Oct 10;250:102-11. doi: 10.1016/j.neuroscience.2013.06.058. Epub 2013 Jul 8. PMID: 23845746.

Ethynylestradiol 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.37mL

0.67mL

0.34mL

16.87mL

3.37mL

1.69mL

33.74mL

6.75mL

3.37mL

Ethynylestradiol 技术信息

CAS号57-63-6
分子式C20H24O2
分子量 296.403
别名 乙炔基雌二醇 ;17α-Ethynylestradiol;Ethinylestradiol;Progynon C;Brand of Ethinyl Estradiol;Organon;Microfollin Forte;Ginestrene;Ethinyloestradiol;Ethynyl E2;Ethynyl 17β-Oestradiol;Ethynyl 17β-Estradiol;Ethynyl β-Estradiol
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature

溶解度

DMSO: 105 mg/mL(354.25 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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