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Doxycycline hyclate
盐酸强力霉素 /Doxycycline hyclate
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货号：A148893
同义名：
多西环素盐酸盐半乙醇半水合物
/ WC2031;Doxycycline hydrochloride hemiethanolate hemihydrate
Doxycycline hyclate是一种口服活性、广谱抗生素 和金属蛋白 酶（MMP ）抑制剂。它表现出抗菌和抗癌细胞增殖活性。
Doxycycline hyclate 化学结构
Doxycycline hyclate 3D分子结构
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Doxycycline hyclate 纯度/质量文件 产品仅供科研
货号：A148893
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Doxycycline hyclate 质控信息
Doxycycline hyclate 生物活性
描述
Doxycycline hyclate is a common broad-spectrum antibiotic. It is also an inhibitor of MMP-8 (nuclear collagenase; IC50 = 30 μM). It also has a certain inhibitory effect on MMP-1 (collagenase-1, IC50 = 300 μM). Its adequate oral absorption and extended half-life, which allows fewer daily doses. Doxycycline hyclate is considered the tetracycline of choice in patients with poor renal function due to its limited clearance by kidneys. It is active against protozoa and can be administered in combination with quinine in the management of chloroquine resistant plasmodium falciparum infection[3]
Doxycycline hyclate 参考文献
[1] Almazin SM, Dziak R, et al. The effect of doxycycline hyclate, chlorhexidine gluconate, and minocycline hydrochloride on osteoblastic proliferation and differentiation in vitro. J Periodontol. 2009 Jun;80(6):999-1005.
[2] Breitschwerdt EB, Hegarty BC, Hancock SI. Doxycycline hyclate treatment of experimental canine ehrlichiosis followed by challenge inoculation with two Ehrlichia canis strains. Antimicrob Agents Chemother. 1998 Feb;42(2):362-8.
[3] Kogawa AC, Zoppi A, Quevedo MA, Nunes Salgado HR, Longhi MR. Increasing doxycycline hyclate photostability by complexation with β-cyclodextrin. AAPS PharmSciTech. 2014;15(5):1209-1217.
Doxycycline hyclate 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
0.97mL
0.19mL
0.10mL
4.87mL
0.97mL
0.49mL
9.75mL
1.95mL
0.97mL
Doxycycline hyclate 技术信息
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