Doxycycline hyclate

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Chemical Structure| 24390-14-5 同义名 : 多西环素盐酸盐半乙醇半水合物 ;WC2031;Doxycycline hydrochloride hemiethanolate hemihydrate;Doxycycline (hyclate)
CAS号 : 24390-14-5
货号 : A148893
分子式 : C46H58Cl2N4O18
纯度 : 97%
分子量 : 1025.875
MDL号 : MFCD07357237
存储条件：

Pure form Keep in dark place,Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 200 mg/mL(194.96 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 120 mg/mL(116.97 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Doxycycline hyclate is a common broad-spectrum antibiotic. It is also an inhibitor of MMP-8 (nuclear collagenase; IC50 = 30 μM). It also has a certain inhibitory effect on MMP-1 (collagenase-1, IC50 = 300 μM). Its adequate oral absorption and extended half-life, which allows fewer daily doses. Doxycycline hyclate is considered the tetracycline of choice in patients with poor renal function due to its limited clearance by kidneys. It is active against protozoa and can be administered in combination with quinine in the management of chloroquine resistant plasmodium falciparum infection[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.97mL

0.19mL

0.10mL

4.87mL

0.97mL

0.49mL

9.75mL

1.95mL

0.97mL
参考文献

[1]Almazin SM, Dziak R, et al. The effect of doxycycline hyclate, chlorhexidine gluconate, and minocycline hydrochloride on osteoblastic proliferation and differentiation in vitro. J Periodontol. 2009 Jun;80(6):999-1005.

[2]Breitschwerdt EB, Hegarty BC, Hancock SI. Doxycycline hyclate treatment of experimental canine ehrlichiosis followed by challenge inoculation with two Ehrlichia canis strains. Antimicrob Agents Chemother. 1998 Feb;42(2):362-8.

[3]Kogawa AC, Zoppi A, Quevedo MA, Nunes Salgado HR, Longhi MR. Increasing doxycycline hyclate photostability by complexation with β-cyclodextrin. AAPS PharmSciTech. 2014;15(5):1209-1217.