Diosgenin, a natural product isolated and purified from the rhizomes of Dioscorea zingiberensis C.H.Wright, is an important natural source of steroidal hormones, and has favorable effects in the improvement of diabetes and regulation of lipid metabolism.
Diosgenin, a steroidal saponin, inhibits the STAT3 signaling pathway[1]. It also acts as an exogenous activator of Pdia3/ERp57[2]. Diosgenin diminishes the progression of aortic atherosclerosis by decreasing macrophage miR-19b expression[5].
体内研究
Additionally, diosgenin significantly reduces fasted and refed blood glucose levels in high-fat diet-fed mice and improves glucose tolerance in the IPGTT[4].
体外研究
At 1 μM in MC65 cells, diosgenin shows protective properties and is considered a potential candidate for compounds targeting Alzheimer's disease (AD) pathology[3].
Diosgenin dose-dependently inhibits the constitutive activation of STAT3 in C3A cells, with maximum inhibition at around 100 μM[1].
At 10 μM, diosgenin significantly decreases miR-19b levels in foam cells after 24 hours[5].
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