薯蓣皂素 /Diosgenin
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货号：A136414
同义名：
Nitogenin;3β-hydroxy-5-Spirostene
Diosgenin 是从姜黄薯 (Dioscorea zingiberensis C.H.Wright) 提取的甾体皂苷，是类固醇激素的重要天然来源。Diosgenin 抑制 STAT3 信号通路，并通过激活 Pdia3/ERp57 和调节巨噬细胞 miR-19b 的表达，显示出抗动脉粥样硬化、调节脂质代谢和改善糖尿病的作用。
Diosgenin 化学结构
Diosgenin 3D分子结构
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Diosgenin 纯度/质量文件 产品仅供科研
货号：A136414
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产品说明书
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Diosgenin 质控信息
Diosgenin 生物活性
描述
Diosgenin, a steroidal saponin, inhibits the STAT3 signaling pathway[1] [2] [5]
体内研究
Additionally, diosgenin significantly reduces fasted and refed blood glucose levels in high-fat diet-fed mice and improves glucose tolerance in the IPGTT[4]
体外研究
At 1 μM in MC65 cells, diosgenin shows protective properties and is considered a potential candidate for compounds targeting Alzheimer's disease (AD) pathology[3]
Diosgenin dose-dependently inhibits the constitutive activation of STAT3 in C3A cells, with maximum inhibition at around 100 μM[1]
At 10 μM, diosgenin significantly decreases miR-19b levels in foam cells after 24 hours[5]
Diosgenin 动物研究
Dose
Rat: 50 mg/kg, 100 mg/kg[5] [6] [7]
Administration
i.g., p.o.
Diosgenin 参考文献
[1] Li F, et al. Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. Cancer Lett. 2010 Jun 28;292(2):197-207.
[2] Tohda C, et al. Diosgenin is an exogenous activator of 1,25D₃-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice. Sci Rep. 2012;2:535.
[3] Jeremy E. Chojnacki, et al. Bivalent ligands incorporating curcumin and diosgenin as
multifunctional compounds against Alzheimer’s disease. Bioorganic & Medicinal Chemistry, 23 (2015) 7324–7331
[4] Wang X, et al. Effect of diosgenin on metabolic dysfunction: Role of ERβ in the regulation of PPARγ. Toxicol Appl Pharmacol. 2015 Dec 1;289(2):286-96.
[5] Yun-cheng Lv, et al. Diosgenin Inhibits Atherosclerosis via Suppressing the MiR-19b-induced Downregulation of ATP-binding Cassette Transporter A1. Atherosclerosis, 2014, 240(1), 80-89.
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Diosgenin 实验方案
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摩尔计算器
总药量计算器
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存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.41mL
0.48mL
0.24mL
12.06mL
2.41mL
1.21mL
24.12mL
4.82mL
2.41mL
Diosgenin 技术信息
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