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Dihomo-γ-linolenic acid {[allProObj[0].p_purity_real_show]}

货号:A320023 同义名: DGLA;all-cis-8,11,14-Eicosatrienoic acid Ambeed 开学季,买赠积分,赢豪礼

Dihomo-γ-linolenic acid (DGLA) 是一种20碳 ω-6 脂肪酸,具有抗炎和抗增殖活性。二高-γ-亚麻酸在载脂蛋白 E 缺乏的小鼠模型中可减轻动脉粥样硬化。

Dihomo-γ-linolenic acid 化学结构 CAS号:1783-84-2
Dihomo-γ-linolenic acid 化学结构
CAS号:1783-84-2
Dihomo-γ-linolenic acid 3D分子结构
CAS号:1783-84-2
Dihomo-γ-linolenic acid 化学结构 CAS号:1783-84-2
Dihomo-γ-linolenic acid 3D分子结构 CAS号:1783-84-2
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Dihomo-γ-linolenic acid 生物活性

描述 Dihomo-γ-linolenic acid (DGLA) is a 20-carbon ω-6 fatty acid noted for its anti-inflammatory and anti-proliferative properties. It is effective in reducing atherosclerosis in apolipoprotein E-deficient mice, a commonly used model for studying this condition[1].[2].[3].
体内研究

In cancer research, DGLA at a dosage of 8 mg per mouse, administered intragastrically twice a week for 35 days, has been effective in suppressing the growth of xenograft tumors in mice implanted with human pancreatic cancer cells (BxPC-3) that have been transfected with delta-5-desaturase shRNA, highlighting its potential therapeutic applications in oncology[3].

体外研究

DGLA also reduces the expression of pro-inflammatory genes in human and mouse macrophages[2].

Specifically, when administered at a concentration of 50 μM for 24 hours, DGLA lessens the phosphorylation of STAT1 on serine 727 induced by IFN-γ[2].

Dihomo-γ-linolenic acid also diminishes the expression of MCP-1 and ICAM-1, which are induced by IL-1β and TNF-α, in human macrophages[2].

Furthermore, DGLA has been shown to inhibit chemokine-driven monocytic migration and the formation of macrophage foam cells, which are key processes in the development of atherosclerosis[2].

Dihomo-γ-linolenic acid 参考文献

[1]Wang X, et al. Multiple roles of dihomo-γ-linolenic acid against proliferation diseases. Lipids Health Dis. 2012 Feb 14;11:25.

[2]Gallagher H, et al. Dihomo-γ-linolenic acid inhibits several key cellular processes associated with atherosclerosis. Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2538-2550.

[3]Yang X, et al. Dihomo-γ-linolenic acid inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA. Redox Biol. 2019 Jan;20:236-246.

Dihomo-γ-linolenic acid 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.26mL

0.65mL

0.33mL

16.31mL

3.26mL

1.63mL

32.63mL

6.53mL

3.26mL

Dihomo-γ-linolenic acid 技术信息

CAS号1783-84-2
分子式C20H34O2
分子量 306.483
别名 DGLA;all-cis-8,11,14-Eicosatrienoic acid;Diroleuton;γ-​Homolinolenic Acid;cis-8,11,14-Eicosatrienoic Acid
运输蓝冰
存储条件

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 105 mg/mL(342.6 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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