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Dihomo-γ-linolenic acid

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Chemical Structure| 1783-84-2 同义名 : DGLA;all-cis-8,11,14-Eicosatrienoic acid;Diroleuton;γ-​Homolinolenic Acid;cis-8,11,14-Eicosatrienoic Acid
CAS号 : 1783-84-2
货号 : A320023
分子式 : C20H34O2
纯度 : 98%
分子量 : 306.483
MDL号 : MFCD00065721
存储条件:

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(342.6 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Dihomo-γ-linolenic acid (DGLA) is a 20-carbon ω-6 fatty acid noted for its anti-inflammatory and anti-proliferative properties. It is effective in reducing atherosclerosis in apolipoprotein E-deficient mice, a commonly used model for studying this condition[1].[2].[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.26mL

0.65mL

0.33mL

16.31mL

3.26mL

1.63mL

32.63mL

6.53mL

3.26mL

参考文献

[1]Wang X, et al. Multiple roles of dihomo-γ-linolenic acid against proliferation diseases. Lipids Health Dis. 2012 Feb 14;11:25.

[2]Gallagher H, et al. Dihomo-γ-linolenic acid inhibits several key cellular processes associated with atherosclerosis. Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2538-2550.

[3]Yang X, et al. Dihomo-γ-linolenic acid inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA. Redox Biol. 2019 Jan;20:236-246.