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货号:A370994 同义名: Dectamine;Dictamine Ambeed 开学季,买赠积分,赢豪礼

Dictamnine, a natural product isolated and purified from the root barks of Dictamnus dasycarpus Turcz., has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells, and has antimicrobial activity against bacteria and fungi.

Dictamnine 化学结构 CAS号:484-29-7
Dictamnine 化学结构
CAS号:484-29-7
Dictamnine 3D分子结构
CAS号:484-29-7
Dictamnine 化学结构 CAS号:484-29-7
Dictamnine 3D分子结构 CAS号:484-29-7
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Dictamnine 纯度/质量文件 产品仅供科研

货号:A370994 标准纯度: {[allProObj[0].p_purity_real_show]}
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Dictamnine 生物活性

描述 Dictamnine, a natural plant product, has been reported to have antimicrobial activity against bacteria and fungi. Dictamnine has antimicrobial activities against the model fungus Saccharomyces cerevisiae, with a minimum inhibitory concentration (MIC) value of 64 microg/ml[3]. Dictamnine exhibited no obvious antibacterial activity against UPEC, but significantly impeded the ability of UPEC (Uropathogenic Escherichia coli) to adhere to and invade uroepithelial cells[4]. Among all cancer cell lines tested, Dic inhibited the proliferation of c-Met-dependent EBC-1 cells with the greatest potency (IC50 = 2.811 μM). Notably, Dic was shown to synergistically improve the chemo-sensitivity of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI)-resistant lung cancer cells to gefitinib and osimertinib[5]. Dic induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which mitochondria and caspase were not involved and DHA (dihydroartemisinin) enhanced Dic induced A549 cell apoptosis via a caspase-dependent pathway[6].

Dictamnine 参考文献

[1]An FF, Liu YC, et al. Dihydroartemisinine enhances dictamnine-induced apoptosis via a caspase dependent pathway in human lung adenocarcinoma A549 cells. Asian Pac J Cancer Prev. 2013;14(10):5895-900.

[2]Guo N, Yu L, et al. Global gene expression profile of Saccharomyces cerevisiae induced by dictamnine. Yeast. 2008 Sep;25(9):631-41.

[3]Guo N, Yu L, Meng R, Fan J, Wang D, Sun G, Deng X. Global gene expression profile of Saccharomyces cerevisiae induced by dictamnine. Yeast. 2008 Sep;25(9):631-41

[4]Yang W, Liu P, Chen Y, Lv Q, Wang Z, Huang W, Jiang H, Zheng Y, Jiang Y, Sun L. Dictamnine Inhibits the Adhesion to and Invasion of Uropathogenic Escherichia Coli (UPEC) to Urothelial Cells. Molecules. 2022 Jan 2;27(1):272

[5]Yu J, Zhang L, Peng J, Ward R, Hao P, Wang J, Zhang N, Yang Y, Guo X, Xiang C, An S, Xu TR. Dictamnine, a novel c-Met inhibitor, suppresses the proliferation of lung cancer cells by downregulating the PI3K/AKT/mTOR and MAPK signaling pathways. Biochem Pharmacol. 2022 Jan;195:114864

[6]An FF, Liu YC, Zhang WW, Liang L. Dihydroartemisinine enhances dictamnine-induced apoptosis via a caspase dependent pathway in human lung adenocarcinoma A549 cells. Asian Pac J Cancer Prev. 2013;14(10):5895-900

Dictamnine 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.02mL

1.00mL

0.50mL

25.10mL

5.02mL

2.51mL

50.20mL

10.04mL

5.02mL

Dictamnine 技术信息

CAS号484-29-7
分子式C12H9NO2
分子量 199.205
别名 Dectamine;Dictamine
运输蓝冰
存储条件

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 50 mg/mL(251 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

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