DUB-IN-1是一种泛素特异性蛋白酶 (USP) 的活性抑制剂,对 USP7 和 USP8 的 IC50 分别为 18 μM 和 0.71 μM,能够有效抑制相关酶活性。
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Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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产品名称 | DUB ↓ ↑ | UCH ↓ ↑ | USP/UBP ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PR-619 |
+
Plpro, EC50: 14.2 μM |
+++
UCH-L3, EC50: 2.95 μM UCH-L5, EC50: 12.8 μM |
+++
USP28, EC50: 6.24 μM USP5, EC50: 4.90 μM |
99%+ | |||||||||||||||
Degrasyn | ✔ | Bcr-Abl | 98+% | ||||||||||||||||
VLX1570 |
+
DUB, IC50: ~10 μM |
99%+ | |||||||||||||||||
ML-323 |
++++
USP1-UAF1, IC50: 76 nM |
99%+ | |||||||||||||||||
LDN-57444 |
++++
UCH-L1, IC50: 0.4 μM UCH-L3, IC50: 25 μM |
99%+ | |||||||||||||||||
TCID |
++++
UCH-L3, IC50: 0.6 μM |
98% | |||||||||||||||||
b-AP15 |
+++
UCHL5, IC50: 2.1 μM |
98% | |||||||||||||||||
P 22077 |
++
USP47, EC50: 8.74 μM USP7, IC50: 8.6 μM |
99%+ | |||||||||||||||||
P005091 |
++
USP7, EC50: 4.2 μM USP47, IC50: 4.3 μM |
99+% | |||||||||||||||||
IU1 |
++
USP14, IC50: 4.7 μM |
98% | |||||||||||||||||
NSC632839 |
+
USP7, EC50: 37 μM USP2, EC50: 45 μM |
99%+ | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | DUB-IN-1 effectively inhibits ubiquitin-specific proteases (USPs) with an IC50 of 0.85 μM against USP8[1]. |
体外研究 | DUBs-IN-1 (22d) actively inhibits ubiquitin-specific proteases with an IC50 of 0.85 μM for USP8 and shows no activity against USP7 (IC50 >100 μM). It and its derivatives decrease the viability of HCT116 colon and PC-3 prostate cancer cell lines with IC50 values between 0.5 μM and 1.5 μM[1]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.96mL 0.59mL 0.30mL |
14.82mL 2.96mL 1.48mL |
29.64mL 5.93mL 2.96mL |
CAS号 | 924296-18-4 |
分子式 | C20H11N5O |
分子量 | 337.334 |
别名 | Dubs-in-1 |
运输 | 蓝冰 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Sealed in dry,Store in freezer, under -20°C |
溶解度 |
DMSO: 105 mg/mL(311.26 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |