葫芦素B /Cucurbitacin B {[allProObj[0].p_purity_real_show]}
货号：A380132同义名：
Cuc B;NSC 144154
Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and could repress cancer cell progression.
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Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Microtubule, a component of the cytoskeleton, plays crucial roles in various fundamental cell functions, including mitotic regulation, maintenance of cell morphology, intracellular motility and macromolecules and organelles trafficking. Cucurbitacin B, an oxygenated tetracyclic triterpenoid compound extracted from the Thai medicinal plant Trichosanthes cucumerina L., has several biological activities including anti-inflammatory, antimicrobial and anticancer through disruption of the microtubule network. It exhibited a dose-dependent inhibitory effect with the IC50 of 4.12 μM and 3.68 μM for MCF-7 and MDA-MB-231 cells, respectively. In the same cell lines treated with 2.5 μM and 5 μM cucurbitacin B for 24 hr, blockage at G2/M and apoptotic induction were observed in cucurbitacin B-treated cells. Further, cucurbitacin B treatment for 24 hr significantly induced apoptosis approximately 30% to 40% of breast cancer cells population. Compared with the control cells, cucurbitacin B treated cells exhibited obvious aggregation of α-tubulin. The changes were observed within 15 min during incubation with cucurbitacin B[3]. In the nude mice bearing human MDA-MB-231 breast cancer cells, tumor volume was reduced by 55% in the group that received Cucurbitacin B (1.0 mg/kg) for 6 weeks compared with vehicle controls[4].
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