Cephalotaxine is a benzazepine alkaloid isolated from Cephalotaxus harringtonia with function of antiviral and antitumor.
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Cephalotaxlen is an alkaloid that can be isolated from Cephalotaxus drupacea, with antileukemic and antiviral activities[3]. CET (Cephalotaxine) activated the mitochondrial apoptosis pathway by reducing the mitochondrial membrane potential, downregulating anti-apoptotic Bcl-2 protein and upregulating pro-apoptotic Bak protein. CET blocked the fluorescence colocation of MitoTracker Green and LysoTracker Red and upregulated the level of LC3-II and p62, which indicated that autophagy flow was impaired. CET could impair lysosomal acidification and block autophagy flow. Finally, inhibiting autophagy flow could aggravate apoptosis of HL-60 cells induced by CET[4]. Cephalotaxine was effective in inhibiting ZIKV (Zika virus) activity in vitro (i.e., in Vero and A549 cell lines). CET (Cephalotaxine) was found to decrease ZIKV RNA and viral protein expression, inhibit ZIKV replication, and inhibit ZIKV mRNA/protein production[5].
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