CDN1163 is an allosteric sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activator that improves Ca2+ homeostasis. CDN1163 attenuates diabetes and metabolic disorders.
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产品名称 | ATPase ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
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(-)-Blebbistatin | 99%+ | ||||||||||||||||||
PF 03716556 |
++++
H+/K+-ATPase, pIC50: ~6.5 |
99%+ | |||||||||||||||||
Esomeprazole sodium | ✔ | 98% | |||||||||||||||||
BTB06584 | ✔ | 99%+ | |||||||||||||||||
Ciclopirox | ✔ | 99%+ | |||||||||||||||||
CB-5083 |
++++
p97 AAA ATPase, IC50: 11 nM |
99%+ | |||||||||||||||||
Ciclopirox olamine | ✔ | 99% | |||||||||||||||||
Brefeldin A |
+++
ATPase (HCT 116), IC50: 0.2 μM |
99%+ | |||||||||||||||||
Oligomycin A | ✔ | 99% | |||||||||||||||||
Sodium orthovanadate |
+++
(Na,K)-ATPase, IC50: 40 nM |
99% | |||||||||||||||||
Golgicide A | ✔ | 99%+ | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | The sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pumps Ca2+ from the cytoplasm into the endoplasmic reticulum (ER). CDN1163 is a small-molecule allosteric activator of SERCA that acts directly on SERCA and improves Ca2+ homeostasis. CDN1163 at 1 – 11μM dose-dependently increased the Vmax of SERCA2 Ca2+-ATPase activity in the ER microsomes from liver tissues. CDN1163 at 10μM rescued cells from H2O2-stimulated cell death. In ob/ob male mice, intraperitoneal injection with 300μL of CDN1163 (50mg/kg/day) for 5 days reduced blood glucose levels and improved metabolic parameters compared with the vehicle-treated group. Treatment with CDN1163 also resulted in a 16% decrease in adipose tissue weight, reduced gluconeogenic gene expression, reversed hepatic steatosis, and inhibited ER stress and ER stress-induced apoptosis in ob/ob mice[3]. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
3.12mL 0.62mL 0.31mL |
15.61mL 3.12mL 1.56mL |
31.21mL 6.24mL 3.12mL |
CAS号 | 892711-75-0 |
分子式 | C20H20N2O2 |
分子量 | 320.385 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(327.73 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |