产品说明书
CDN1163
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同义名 : | - |
| CAS号 : | 892711-75-0 | |
| 货号 : | A587120 | |
| 分子式 : | C20H20N2O2 | |
| 纯度 : | 99%+ | |
| 分子量 : | 320.385 | |
| MDL号 : | MFCD07177494 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(327.73 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | The sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pumps Ca2+ from the cytoplasm into the endoplasmic reticulum (ER). CDN1163 is a small-molecule allosteric activator of SERCA that acts directly on SERCA and improves Ca2+ homeostasis. CDN1163 at 1 – 11μM dose-dependently increased the Vmax of SERCA2 Ca2+-ATPase activity in the ER microsomes from liver tissues. CDN1163 at 10μM rescued cells from H2O2-stimulated cell death. In ob/ob male mice, intraperitoneal injection with 300μL of CDN1163 (50mg/kg/day) for 5 days reduced blood glucose levels and improved metabolic parameters compared with the vehicle-treated group. Treatment with CDN1163 also resulted in a 16% decrease in adipose tissue weight, reduced gluconeogenic gene expression, reversed hepatic steatosis, and inhibited ER stress and ER stress-induced apoptosis in ob/ob mice[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.12mL 0.62mL 0.31mL |
15.61mL 3.12mL 1.56mL |
31.21mL 6.24mL 3.12mL |
| 参考文献 |
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