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盐酸苄丝肼 /Benserazide HCI {[allProObj[0].p_purity_real_show]}

货号:A983665 同义名: Serazide;Ro 4-4602 Ambeed 开学季,买赠积分,赢豪礼

Benserazide HCl is a aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.

Benserazide HCI 化学结构 CAS号:14919-77-8
Benserazide HCI 化学结构
CAS号:14919-77-8
Benserazide HCI 3D分子结构
CAS号:14919-77-8
Benserazide HCI 化学结构 CAS号:14919-77-8
Benserazide HCI 3D分子结构 CAS号:14919-77-8
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Benserazide HCI 纯度/质量文件 产品仅供科研

货号:A983665 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 decarboxylase 其他靶点 纯度
Eflornithine hydrochloride hydrate {[allProObj[0].p_purity_real_show]}
Methyldopa {[allProObj[0].p_purity_real_show]}
Benserazide HCI {[allProObj[0].p_purity_real_show]}
Carbidopa +++

aromatic-L-amino-acid decarboxylase, IC50: 29 μM

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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Benserazide HCI 生物活性

靶点
  • decarboxylase

描述 Benserazide hydrochloride is commonly used in Parkinson's disease and is an inhibitor of peripheral aromatic L-amino acid decarboxylase (AADC). Benserazide reduces the central AADC activity in the striatum of rats with nigrostriatal denervation, which leads to changes in the metabolism of exogenous L-DOPA[2]. Benserazide hydrochloride (BH) and Levodopa (LD) individually and in combination (BH + LD) (25 μM; 0 hour, 12 hours, 24 hours and 168 hours; SH-SY5Y) treatment inhibit protein aggregation and have the ability to minimise the amyloid-induced cytotoxicity in human neuroblastoma cell line. Benserazide hydrochloride and LD both can act as efficient inhibitors of the formation of cytotoxic HSA aggregates, and the inhibitory effects are more pronounced when both of these drugs are added simultaneously[3]. Under dopaminergic nigrostriatal denervation, treatment with L-DOPA/BE ameliorated colonic motility through a normalization of myenteric cholinergic neurotransmission, along with an improvement of colonic inflammation[4].

Benserazide HCI 参考文献

[1]Shen H, Kannari K, et al. Effects of benserazide on L-DOPA-derived extracellular dopamine levels and aromatic L-amino acid decarboxylase activity in the striatum of 6-hydroxydopamine-lesioned rats. Tohoku J Exp Med. 2003 Mar;199(3):149-59.

[2]Shen H, Kannari K, Yamato H, Arai A, Matsunaga M. Effects of benserazide on L-DOPA-derived (L-3,4-dihydroxyphenylalanine) extracellular dopamine levels and aromatic L-amino acid decarboxylase activity in the striatum of 6-hydroxydopamine-lesioned rats. Tohoku J Exp Med. 2003 Mar;199(3):149-59

[3]Chandel TI, Zaidi N, Zaman M, Jahan I, Masroor A, Siddique IA, Nayeem SM, Ali M, Uversky VN, Khan RH. A multiparametric analysis of the synergistic impact of anti-Parkinson's drugs on the fibrillation of human serum albumin. Biochim Biophys Acta Proteins Proteom. 2019 Mar;1867(3):275-285

[4]Pellegrini C, Antonioli L, Colucci R, Tirotta E, Gentile D, Ippolito C, Segnani C, Levandis G, Cerri S, Blandini F, Barocelli E, Ballabeni V, Bernardini N, Blandizzi C, Fornai M. Effects of L-DOPA/benserazide co-treatment on colonic excitatory cholinergic motility and enteric inflammation following dopaminergic nigrostriatal neurodegeneration. Neuropharmacology. 2017 Sep 1;123:22-33

Benserazide HCI 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.40mL

0.68mL

0.34mL

17.02mL

3.40mL

1.70mL

34.05mL

6.81mL

3.40mL

Benserazide HCI 技术信息

CAS号14919-77-8
分子式C10H16ClN3O5
分子量 293.704
别名 Serazide;Ro 4-4602;Benserazide (hydrochloride);Benserazide HCl
运输蓝冰
存储条件

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 105 mg/mL(357.5 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 50 mg/mL(170.24 mM)

动物实验配方
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