货号:A587591 同义名: (S)-(-)-Carbidopa
Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM.
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产品名称 | decarboxylase ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
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Eflornithine hydrochloride hydrate | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Methyldopa | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Benserazide HCI | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Carbidopa |
+++
aromatic-L-amino-acid decarboxylase, IC50: 29 μM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
靶点 |
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描述 | Aromatic L-amino acid decarboxylase (AADC) is the final enzyme in the biosynthesis of the monoamine neurotransmitters serotonin and dopamine, and dopamine is the precursor for norepinephrine and epinephrine[3]. Carbidopa (CD), a competitive inhibitor of AADC that doesn’t cross the blood-brain barrier, is routinely administered with levodopa (LD) to patients with Parkinson disease (PD) to reduce the peripheral decarboxylation of LD to dopamine[4]. On exposure to other human tumor lines, CD was lethal only to NCI-H146 and NCI-H209 small cell lung carcinoma (SCLC) lines (IC50 = 12 ± 1 μM and 22 ± 5 μM, respectively). CD (100 μM) decreased growth of SK-N-SH neuroblastoma and A204 rhabdomyosarcoma cells[5]. For all patients with cerebrospinal fluid (CSF), AUC (area under the curve) serum CD significantly correlated with percent-labeled CSF HVA (R = 0.786, p = 0.02). In addition, a significantly greater percent-labeled CSF HVA was present in “rapid” as compared to “slow” CD absorbers (Patients were divided into “slow” absorbers (those unable to attain a serum CD level of at least 300 ng/ml within 3 hours after CD administration) and those with more “rapid” absorption (patients obtaining a level of 300 ng/ml or greater within the first 3 hours))[4]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT01766258 | Parkinson's Disease | Phase 2 | Completed | - | - |
NCT01663935 | Albinism Ocul... 展开 >>ocutaneous Albinism 收起 << | Phase 2 | Recruiting | October 2017 | United States, Wisconsin
... 展开 >>
University of Wisconsin
Recruiting
Madison, Wisconsin, United States, 53705
Contact: Angie Wealti 608-265-7557 Angie Wealti |
NCT01468012 | Cocaine Dependence | Phase 2 Phase 3 | Completed | - | United States, New York ... 展开 >> STARS New York, New York, United States, 10032 收起 << |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
4.42mL 0.88mL 0.44mL |
22.10mL 4.42mL 2.21mL |
44.20mL 8.84mL 4.42mL |
CAS号 | 28860-95-9 |
分子式 | C10H14N2O4 |
分子量 | 226.229 |
别名 | (S)-(-)-Carbidopa |
运输 | 蓝冰 |
存储条件 |
粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 9 mg/mL(39.78 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |
4% DMSO+30% PEG 300+2% Tween 80+water 1 mg/mL |