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/ Benazepril HCl

盐酸贝那普利 /Benazepril HCl {[allProObj[0].p_purity_real_show]}

货号：A430288 同义名： CGS14824A;Benazepril (hydrochloride)

Benazepril HCl is an ACE inhibitor, primarily used in treatment of hypertension. Benazepril HCl is the HCl form of Benazepril.

Benazepril HCl 化学结构 CAS号：86541-74-4
Benazepril HCl 化学结构
CAS号：86541-74-4
Benazepril HCl 3D分子结构
CAS号：86541-74-4
Benazepril HCl 化学结构 CAS号：86541-74-4
Benazepril HCl 3D分子结构 CAS号：86541-74-4
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Benazepril HCl 纯度/质量文件 产品仅供科研

货号：A430288 标准纯度： {[allProObj[0].p_purity_real_show]}
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Benazepril HCl 生物活性

描述 Benazepril hydrochloride, an angiotensin converting enzyme (ACE) inhibitor, which is a medication used to treat high blood pressure. Benazepril decreases ILK(Integrin-linked kinase) and α-SMA (Smooth muscle α-actin) expression by affecting the interactions between Ang II(Angiotensin II) and TGF-β1(Transforming growth factor-β1)[3]. Benazepril hydrochloride improves DN (diabetic nephropathy) and decreases proteinuria by decreasing ANGPTL-4 expression[4]. Combination therapy with amlodipine/benazepril is more effective in BP (blood pressure) lowering than monotherapy with the component drugs[5].

Benazepril HCl 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00000620 Atherosclerosis ... 展开 >> Cardiovascular Diseases Hypercholesterolemia Hypertension Diabetes Mellitus, Type 2 Diabetes Mellitus Coronary Disease 收起 << Phase 3 Completed - United States, Minnesota ... 展开 >> Minneapolis Medical Research Foundation Minneapolis, Minnesota, United States, 55404 United States, New York Columbia University New York, New York, United States, 10027 United States, North Carolina Wake Forest University Winston-Salem, North Carolina, United States, 27106 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 United States, Tennessee Veterans Affairs Memphis, Tennessee, United States, 38104 United States, Washington University of Washington Seattle, Washington, United States, 98195 Canada, Ontario McMaster University Hamilton, Ontario, Canada 收起 <<
NCT01076205 - Completed - -
NCT01669434 - Completed - -

Benazepril HCl 参考文献

[1]Yamamoto S, Takemori E, et al. General pharmacology of the novel angiotensin converting enzyme inhibitor benazepril hydrochloride. Effects on central nervous and sensory systems and other functions. Arzneimittelforschung. 1991 Jun;41(6):602-7.

[2]Yamamoto S, Takemori E, et al. General pharmacology of the novel angiotensin converting enzyme inhibitor benazepril hydrochloride. Effects on cardiovascular, visceral and renal functions and on hemodynamics. Arzneimittelforschung. 1991 Sep;41(9):913-23.

[3]Niu H, Nie L, Liu M, Chi Y, Zhang T, Li Y. Benazepril affects integrin-linked kinase and smooth muscle α-actin expression in diabetic rat glomerulus and cultured mesangial cells. BMC Nephrol. 2014 Aug 20;15:135. doi: 10.1186/1471-2369-15-135. PMID: 25142208; PMCID: PMC4151867.

[4]Xue L, Feng X, Wang C, Zhang X, Sun W, Yu K. Benazepril hydrochloride improves diabetic nephropathy and decreases proteinuria by decreasing ANGPTL-4 expression. BMC Nephrol. 2017 Oct 4;18(1):307. doi: 10.1186/s12882-017-0724-1. PMID: 28978304; PMCID: PMC5628429.

[5]Chrysant SG. Blood pressure effects of high-dose amlodipine-benazepril combination in Black and White hypertensive patients not controlled on monotherapy. Drugs R D. 2012 Jun 1;12(2):57-64. doi: 10.2165/11633430-000000000-00000. PMID: 22571394; PMCID: PMC3586097.

Benazepril HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.85mL

2.17mL

1.08mL

21.69mL

4.34mL

2.17mL

Benazepril HCl 技术信息

CAS号86541-74-4
分子式C24H29ClN2O5
分子量 460.95
别名 CGS14824A;Benazepril (hydrochloride);CGS 14824A HCl;Benazepril hydrochloride
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature
溶解度

DMSO: 105 mg/mL(227.79 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 10 mg/mL(21.69 mM)，配合低频超声助溶
动物实验配方

PO 0.5% CMC-Na 50 mg/mL suspension

Tags: Benazepril | 86541-74-4 | CGS14824A | Angiotensin-converting Enzyme (ACE) | ACE Inhibitor | Metabolic Enzyme/Protease | Angiotensin-converting Enzyme (ACE) | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Benazepril HCl 纯度/质量文件 | Benazepril HCl 生物活性 | Benazepril HCl 临床数据 | Benazepril HCl 参考文献 | Benazepril HCl 实验方案 | Benazepril HCl 技术信息

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