产品说明书
Benazepril HCl
 |
同义名 : | CGS14824A;Benazepril (hydrochloride);CGS 14824A HCl;Benazepril hydrochloride |
| CAS号 : | 86541-74-4 | |
| 货号 : | A430288 | |
| 分子式 : | C24H29ClN2O5 | |
| 纯度 : | 98% | |
| 分子量 : | 460.95 | |
| MDL号 : | MFCD00895734 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 105 mg/mL(227.79 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 10 mg/mL(21.69 mM)，配合低频超声助溶 |
|
| 动物实验配方： |
PO 0.5% CMC-Na 50 mg/mL suspension |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Benazepril hydrochloride, an angiotensin converting enzyme (ACE) inhibitor, which is a medication used to treat high blood pressure. Benazepril decreases ILK(Integrin-linked kinase) and α-SMA (Smooth muscle α-actin) expression by affecting the interactions between Ang II(Angiotensin II) and TGF-β1(Transforming growth factor-β1)[3]. Benazepril hydrochloride improves DN (diabetic nephropathy) and decreases proteinuria by decreasing ANGPTL-4 expression[4]. Combination therapy with amlodipine/benazepril is more effective in BP (blood pressure) lowering than monotherapy with the component drugs[5]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00000620 | Atherosclerosis ... 展开 >> Cardiovascular Diseases Hypercholesterolemia Hypertension Diabetes Mellitus, Type 2 Diabetes Mellitus Coronary Disease 收起 << | Phase 3 | Completed | - | United States, Minnesota ... 展开 >> Minneapolis Medical Research Foundation Minneapolis, Minnesota, United States, 55404 United States, New York Columbia University New York, New York, United States, 10027 United States, North Carolina Wake Forest University Winston-Salem, North Carolina, United States, 27106 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 United States, Tennessee Veterans Affairs Memphis, Tennessee, United States, 38104 United States, Washington University of Washington Seattle, Washington, United States, 98195 Canada, Ontario McMaster University Hamilton, Ontario, Canada 收起 << |
| NCT01076205 | - | Completed | - | - | |
| NCT01669434 | - | Completed | - | - | |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.17mL 0.43mL 0.22mL |
10.85mL 2.17mL 1.08mL |
21.69mL 4.34mL 2.17mL |
| 参考文献 |
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