Bavachin is a component purified from ethanolic extract of Psoralea corylifolia. It activates estrogen receptors ERα and ERβ in Cv-1 cells with EC50 values of 320 nM and 680 nM, respectively. Bavachin displaced the [3H] E2 with IC50 values of 6.57×10-5M and 3.8×10-5M for hERα and hERβ, respectively. The treatment with breast cancer cell line MCF-7 with 10 μM bavachin for 12 h downregulated the protein level of ERα compared to the vehicle control. In MCF-7 BOS cells, treatment with bavachin (0.01 - 1 μM) for 6 days significantly induced cellular proliferation in a dose-dependent manner[3]. In ovariectomized (OVX) rats, treatment with Bavachin (8 mg/kg/day) for 12 weeks significantly reduced the serum level of alkaline phosphatase and increased the level of N-terminal propeptide of procollagen type I compared to the vehicle control group. The administration of bavachin also increased the thickness and integrality of cortical bone in OVX rats[4].
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