Bavachin
产品说明书
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同义名 : | 补骨脂甲素 ;Corylifolin |
| CAS号 : | 19879-32-4 | |
| 货号 : | A193314 | |
| 分子式 : | C20H20O4 | |
| 纯度 : | 99%+ | |
| 分子量 : | 324.37 | |
| MDL号 : | MFCD11617359 | |
| 存储条件： |
Pure form Inert atmosphere,Store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(323.7 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Bavachin is a component purified from ethanolic extract of Psoralea corylifolia. It activates estrogen receptors ERα and ERβ in Cv-1 cells with EC50 values of 320 nM and 680 nM, respectively. Bavachin displaced the [3H] E2 with IC50 values of 6.57×10-5M and 3.8×10-5M for hERα and hERβ, respectively. The treatment with breast cancer cell line MCF-7 with 10 μM bavachin for 12 h downregulated the protein level of ERα compared to the vehicle control. In MCF-7 BOS cells, treatment with bavachin (0.01 - 1 μM) for 6 days significantly induced cellular proliferation in a dose-dependent manner[3]. In ovariectomized (OVX) rats, treatment with Bavachin (8 mg/kg/day) for 12 weeks significantly reduced the serum level of alkaline phosphatase and increased the level of N-terminal propeptide of procollagen type I compared to the vehicle control group. The administration of bavachin also increased the thickness and integrality of cortical bone in OVX rats[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.08mL 0.62mL 0.31mL |
15.41mL 3.08mL 1.54mL |
30.83mL 6.17mL 3.08mL |
| 参考文献 |
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