苍术苷钾盐 /Atractyloside potassium salt {[allProObj[0].p_purity_real_show]}
货号：A230303同义名：
苍术苷二钾盐
/ Atractyloside (potassium salt);ATR potassium salt
Atractyloside is a natural compound that acts both an inhibitor of ANT and an apoptosis inducer.
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HazMat fee for 500 gram (Estimated)
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Limited Quantity
USD 15-60
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USD 80+
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Atractyloside potassium salt 化学结构 CAS号：102130-43-8
Atractyloside potassium salt 3D分子结构 CAS号：102130-43-8
The adenine nucleotide translocator (ANT) accomplishes the exchange of ATP from the mitochondrial matrix with cytoplasmic ADP[1].Atractyloside potassium salt is a toxic diterpenoid glycoside that can be isolated from the fruits of Xanthium sibiricum. Atractyloside potassium salt is a powerful and specific inhibitor of mitochondrial ADP/ATP transport. Atractyloside potassium salt inhibits chloride channels from mitochondrial membranes of rat heart[2].Upon cell-death induction, ANT1 becomes a substrate for type 2 transglutaminase(TG2)'s cross-linking activity and the lack of TG2 results in a reduction of apoptosis as well as in a marked sensitivity to the ADP/ATP exchange inhibition by atractyloside[3].Renal and hepatic pyruvate-stimulated gluconeogenesis were significantly (P < 0.05) inhibited at atractyloside concentrations of > or =500 microM. Accumulation of organic anion p-amino-hippuric acid (PAH) was also inhibited in renal cortical slices at atractyloside concentrations of > or =500 microM[4]. Atractyloside in large amounts gives rise to massive necrosis, but in vitro studies have shown that at lower doses cells progress to apoptosis[5].In vitro proximal tubular cells are selectively sensitive to atractyloside, whereas other renal cell types are quite resistant. There are also differences in the response of liver and renal tissue to atractyloside[6].
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