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Atglistatin {[allProObj[0].p_purity_real_show]}

货号:A241114 Ambeed 开学季,买赠积分,赢豪礼

Atglistatin is a potent, selective and competitive ATGL with IC50 value of 0.7 μM.

Atglistatin 化学结构 CAS号:1469924-27-3
Atglistatin 化学结构
CAS号:1469924-27-3
Atglistatin 3D分子结构
CAS号:1469924-27-3
Atglistatin 化学结构 CAS号:1469924-27-3
Atglistatin 3D分子结构 CAS号:1469924-27-3
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Atglistatin 纯度/质量文件 产品仅供科研

货号:A241114 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 Lipase 其他靶点 纯度
XEN445 +++

endothelial lipase, IC50: 0.237 μM

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JZL184 ++++

MAGL, IC50: 8 nM

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Tanshinone IIA {[allProObj[0].p_purity_real_show]}
Orlistat {[allProObj[0].p_purity_real_show]}
Atglistatin ++

ATGL, IC50: 0.7 μM

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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Atglistatin 生物活性

靶点
  • Lipase

    ATGL, IC50:0.7 μM

描述 Atglistatin targets the triacylglycerol (TG) hydrolase activity of adipose triglyceride lipase (ATGL) in white adipose tissue (WAT), inhibiting it in a dose-dependent manner and achieving up to a 78% reduction at the highest tested concentration. In WAT lysates from ATGL knockout (ko) animals, where TG hydrolase activity is already diminished by about 70%, Atglistatin exerts a moderate effect on the remaining activity. This suggests that the majority of the non-ATGL related TG hydrolase activity can be attributed to hormone-sensitive lipase (HSL), especially since the combined inhibition with Atglistatin and an HSL inhibitor nearly abolishes TG hydrolase activity in WAT (-95%)[1].
体内研究

Administered orally in olive oil, Atglistatin influences plasma and tissue TG levels, among other metabolic parameters, in animals. Lipolytic indicators such as fatty acids (FA) and glycerol show reductions 4 and 8 hours post-administration, with levels returning to baseline after 12 hours. A dose-dependent decrease in FA and glycerol, up to 50% and 62% respectively, is observed 8 hours following treatment. Additionally, Atglistatin significantly lowers plasma TG levels by 43% without affecting blood glucose, total cholesterol, ketone bodies, and insulin levels. These effects are also seen when Atglistatin is administered via intraperitoneal injection, highlighting its potential as an anti-lipolytic agent[1].

体外研究

Atglistatin targets the triacylglycerol (TG) hydrolase activity of adipose triglyceride lipase (ATGL) in white adipose tissue (WAT), inhibiting it in a dose-dependent manner and achieving up to a 78% reduction at the highest tested concentration. In WAT lysates from ATGL knockout (ko) animals, where TG hydrolase activity is already diminished by about 70%, Atglistatin exerts a moderate effect on the remaining activity. This suggests that the majority of the non-ATGL related TG hydrolase activity can be attributed to hormone-sensitive lipase (HSL), especially since the combined inhibition with Atglistatin and an HSL inhibitor nearly abolishes TG hydrolase activity in WAT (-95%)[1].

Atglistatin 参考文献

[1]Mayer N, et al. Development of small-molecule inhibitors targeting adipose triglyceride lipase. (2013) Nat Chem Biol. 9(12):785-7.

Atglistatin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.53mL

0.71mL

0.35mL

17.64mL

3.53mL

1.76mL

35.29mL

7.06mL

3.53mL

Atglistatin 技术信息

CAS号1469924-27-3
分子式C17H21N3O
分子量 283.368
别名
运输蓝冰
存储条件

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 105 mg/mL(370.54 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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