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Apigenin 7-Glucuronide
芹菜素-7-O-葡萄糖醛酸苷 /Apigenin 7-Glucuronide
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货号：A529360
同义名：
芹菜素-7-葡萄糖醛酸
/ Apigenin 7-O-glucuronide
Apigenin-7-glucuronide is a natural product isolated and purified from the herb of Phlomis tuberosa. with antioxidant activity. Apigenin-7-glucuronide inhibits the major pathways of arachidonate metabolism in leukocytes.
Apigenin 7-Glucuronide 化学结构
Apigenin 7-Glucuronide 3D分子结构
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Apigenin 7-Glucuronide 质控信息
Marimastat
+++
MMP-14, IC50: 3 nM
MMP-7, IC50: 16 nM
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Ilomastat
++++
MMP-2, Ki: 0.1 nM
MMP-26, Ki: 0.36 nM
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SB-3CT
+
MMP-2, Ki: 13.9 nM
MMP-9, Ki: 600 nM
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Doxycycline
✔
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Batimastat
+++
MMP-7, IC50: 4 nM
MMP-1, IC50: 3 nM
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Nobiletin
✔
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Apigenin 7-Glucuronide 生物活性
描述
Apigenin-7-glucuronide (A7G) could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively[2] [3] [3]
Apigenin 7-Glucuronide 参考文献
[1] Cui X, Cai H, et al. Simultaneous Determination of 10 Flavonoids in Crude and Wine-Processed Radix scutellariae by UHPLC. J Chromatogr Sci. 2016 Mar;54(3):312-7.
[2] Crascì L, Basile L, Panico A, Puglia C, Bonina FP, Basile PM, Rizza L, Guccione S. Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. Planta Med. 2017 Jul;83(11):901-911
[3] Marrassini C, Cogoi L, Sülsen V, Anesini C. Apigenin-7-Glucuronide from Urera aurantiaca Inhibits Tumor Necrosis Factor Alpha and Total Nitrite Release in Lipopolysaccharide-Activated Macrophages. Evid Based Complement Alternat Med. 2020 Dec 2;2020:6638764
Apigenin 7-Glucuronide 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
2.24mL
0.45mL
0.22mL
11.20mL
2.24mL
1.12mL
22.40mL
4.48mL
2.24mL
Apigenin 7-Glucuronide 技术信息
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