Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 / 抑制剂/激动剂 / 抗感染 / Antifungal / Amorolfine hydrochloride

盐酸阿莫罗芬 /Amorolfine hydrochloride {[allProObj[0].p_purity_real_show]}

货号：A116220 同义名： 盐酸阿莫洛芬 / Ro 14-4767/002;Amorolfine (hydrochloride) Ambeed 开学季，买赠积分，赢豪礼

Amorolfine HCl is a morpholine antifungal drug working by inhibiting Δ-sterol reductase.

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Amorolfine hydrochloride 化学结构 CAS号：78613-38-4
Amorolfine hydrochloride 化学结构
CAS号：78613-38-4
Amorolfine hydrochloride 3D分子结构
CAS号：78613-38-4
Amorolfine hydrochloride 化学结构 CAS号：78613-38-4
Amorolfine hydrochloride 3D分子结构 CAS号：78613-38-4
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} 		{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 咨询 - +
购物车0 收藏 询单

Amorolfine hydrochloride 纯度/质量文件 产品仅供科研

货号：A116220 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• JACS Au, 2024. Ambeed. [ A148168 ]
• JMC, 2024. Ambeed. [ A187643 ]
• JMC, 2024. Ambeed. [ A341145 , A633512 , A607865 , A167774 ]
• Biomacromolecules, 2024. Ambeed. [ A110759 ]
• Biomacromolecules, 2024. Ambeed. [ A203543 ]
更多 >

Amorolfine hydrochloride 生物活性

描述 Amorolfine Hydrochloride is an antifungal showing activity against fungi pathogenic to plants, animals and humans. Amorolfine possesses a broad antifungal spectrum including dermatophytes, yeasts, dimorphic fungi and moulds and is not only fungistatic but fungicidal against most species. Amorolfine clears mycotic foci of trichophytosis in the guinea pig in 10 days, while none of the azoles is able to cure these animals. In vaginal candidosis 0.1% amorolfine clears the vagina of viable candida cells in rats[3]. Polymeric nail lacquers with Eudragit E100 were developed as a potentially suitable delivery system for amorolfine hydrochloride. The results suggest that this novel combination of enhancers has the potential to be an effective option for topical drug delivery through the nail, and increased the efficacy of treatment[4]. In clinical trials, application of amorolfine 5% nail lacquer once or twice weekly for up to 6 months produced mycological and clinical cure in approximately 40 to 55% of patients with mild onychomycosis 3 months after cessation of therapy. Overall cure and improvement was observed in approximately 85 to 90% of patients with superficial dermatomycoses following treatment with amorolfine 0.25% cream for up to 6 weeks[5].

Amorolfine hydrochloride 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02321098 Foot Dermatoses Phase 4 Completed - Iceland ... 展开 >> Principal Investigator Reykjavik, Iceland 收起 <<
NCT03289871 Onychomycosis Not Applicable Completed - Tunisia ... 展开 >> Hospital Habib Thameur Tunis, Tunisia Principal instruction military hospital Tunis, Tunisia 收起 <<
NCT03382717 Onychomycosis of Toenail Not Applicable Completed - Tunisia ... 展开 >> Hospital Habib Thameur Tunis, Tunisia Principal instruction military hospital Tunis, Tunisia 收起 <<

Amorolfine hydrochloride 参考文献

[1]Polak A. Preclinical data and mode of action of amorolfine. Dermatology. 1992;184 Suppl 1:3-7.

[2]Richardson MD, Shankland GS, et al. Effect of amorolfine (Ro 14-4767/002) on in vitro phagocytosis and intracellular killing of Candida albicans by human neutrophils. Mycoses. 1989 May;32(5):245-9.

[3]Polak A. Preclinical data and mode of action of amorolfine. Dermatology. 1992;184 Suppl 1:3‐7

[4]Šveikauskaitė I, Pockevičius A, Briedis V. Potential of Chemical and Physical Enhancers for Transungual Delivery of Amorolfine Hydrochloride. Materials (Basel). 2019;12(7):1028. Published 2019 Mar 28

[5]Haria M, Bryson HM. Amorolfine. A review of its pharmacological properties and therapeutic potential in the treatment of onychomycosis and other superficial fungal infections. Drugs. 1995;49(1):103‐120

Amorolfine hydrochloride 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.83mL

0.57mL

0.28mL

14.13mL

2.83mL

1.41mL

28.25mL

5.65mL

2.83mL

Amorolfine hydrochloride 技术信息

CAS号78613-38-4
分子式C21H36ClNO
分子量 353.97
别名 盐酸阿莫洛芬 ;Ro 14-4767/002;Amorolfine (hydrochloride);Ro 14-4767 HCl;Amorolfine HCl
运输蓝冰
存储条件

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 12 mg/mL(33.9 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 3 mg/mL(8.48 mM)，配合低频超声助溶
动物实验配方

Tags: Amorolfine hydrochloride | Ro 14-4767/002;Amorolfine (hydrochloride);Ro 14-4767 HCl;Amorolfine HCl | 盐酸阿莫洛芬 | Antifungal | AmBeed-信号通路专用抑制剂 | Amorolfine hydrochloride 纯度/质量文件 | Amorolfine hydrochloride 生物活性 | Amorolfine hydrochloride 临床数据 | Amorolfine hydrochloride 参考文献 | Amorolfine hydrochloride 实验方案 | Amorolfine hydrochloride 技术信息

Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 Ambeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z