产品说明书
Amorolfine hydrochloride
 |
同义名 : | 盐酸阿莫洛芬 ;Ro 14-4767/002;Amorolfine (hydrochloride);Ro 14-4767 HCl;Amorolfine HCl |
| CAS号 : | 78613-38-4 | |
| 货号 : | A116220 | |
| 分子式 : | C21H36ClNO | |
| 纯度 : | 98+% | |
| 分子量 : | 353.97 | |
| MDL号 : | MFCD00903738 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 12 mg/mL(33.9 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 3 mg/mL(8.48 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Amorolfine Hydrochloride is an antifungal showing activity against fungi pathogenic to plants, animals and humans. Amorolfine possesses a broad antifungal spectrum including dermatophytes, yeasts, dimorphic fungi and moulds and is not only fungistatic but fungicidal against most species. Amorolfine clears mycotic foci of trichophytosis in the guinea pig in 10 days, while none of the azoles is able to cure these animals. In vaginal candidosis 0.1% amorolfine clears the vagina of viable candida cells in rats[3]. Polymeric nail lacquers with Eudragit E100 were developed as a potentially suitable delivery system for amorolfine hydrochloride. The results suggest that this novel combination of enhancers has the potential to be an effective option for topical drug delivery through the nail, and increased the efficacy of treatment[4]. In clinical trials, application of amorolfine 5% nail lacquer once or twice weekly for up to 6 months produced mycological and clinical cure in approximately 40 to 55% of patients with mild onychomycosis 3 months after cessation of therapy. Overall cure and improvement was observed in approximately 85 to 90% of patients with superficial dermatomycoses following treatment with amorolfine 0.25% cream for up to 6 weeks[5]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT02321098 | Foot Dermatoses | Phase 4 | Completed | - | Iceland ... 展开 >> Principal Investigator Reykjavik, Iceland 收起 << |
| NCT03289871 | Onychomycosis | Not Applicable | Completed | - | Tunisia ... 展开 >> Hospital Habib Thameur Tunis, Tunisia Principal instruction military hospital Tunis, Tunisia 收起 << |
| NCT03382717 | Onychomycosis of Toenail | Not Applicable | Completed | - | Tunisia ... 展开 >> Hospital Habib Thameur Tunis, Tunisia Principal instruction military hospital Tunis, Tunisia 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.83mL 0.57mL 0.28mL |
14.13mL 2.83mL 1.41mL |
28.25mL 5.65mL 2.83mL |
| 参考文献 |
|---|
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[1]Polak A. Preclinical data and mode of action of amorolfine. Dermatology. 1992;184 Suppl 1:3-7. [3]Polak A. Preclinical data and mode of action of amorolfine. Dermatology. 1992;184 Suppl 1:3‐7 |