Alisol A is a bioactive triterpenoid isolated from the Rhizoma Alismatis. Alisol A inhibited the proliferation, migration, and invasion of NPC (nasopharyngeal carcinoma) cells by inhibiting the Hippo signaling pathway. In addition, Alisol A promoted the phosphorylation of YAP and suppressed the expression of YAP in NPC cells[3]. Alisol A remarkably decreased lipid levels, alleviated glucose metabolism disorders and insulin resistance in high-fat-diet-induced obese mice. Alisol A reduced hepatic steatosis and improved liver function in the obese mice model[4]. Alisol A can effectively inhibit the formation of arterial plaques and blocked the progression of AS in ApoE-/- mice fed with high-fat diet and significantly reduced the expression of inflammatory cytokins in aorta, including ICAM-1, IL-6, and MMP-9. Alisol A activated the AMPK/SIRT1 signaling pathway and NF-κB inhibitor IκBα in HepG2 cells[5].
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