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阿巴卡韦 /Abacavir {[allProObj[0].p_purity_real_show]}

货号:A310646 同义名: 1592U89

Abacavir is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Abacavir 化学结构 CAS号:136470-78-5
Abacavir 化学结构
CAS号:136470-78-5
Abacavir 3D分子结构
CAS号:136470-78-5
Abacavir 化学结构 CAS号:136470-78-5
Abacavir 3D分子结构 CAS号:136470-78-5
规格 价格 会员价 库存 数量
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Abacavir 纯度/质量文件 产品仅供科研

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Abacavir 生物活性

描述 Abacavir is a competitive nucleoside reverse transcriptase inhibitor with oral activity. It inhibits HIV replication and displays anticancer potential in prostate cancer cell lines. Additionally, Abacavir can cross the blood-brain barrier and inhibit telomerase activity[1].[2].[3].
体内研究

Furthermore, Abacavir (50 mg/kg/d, administered intraperitoneally for 14 days) in combination with 0.1 mg/kg/d Decitabine enhances survival in mice bearing high-risk medulloblastoma[3].

体外研究

At concentrations of 15 and 150 μM over 0-120 hours, Abacavir suppresses cell growth, affects cell cycle progression, induces senescence, and modulates LINE-1 mRNA expression in prostate cancer cell lines[1].

Also, at the concentration of 15 and 150 μM, Abacavir significantly reduces cell migration and invasion at after 18 hours[1].

Abacavir 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02868580 Amyotrophic Lateral Sclerosis Phase 2 Active, not recruiting June 2018 Australia, New South Wales ... 展开 >> Macquarie Neurology North Ryde, New South Wales, Australia, 2109 Westmead Hospital Parramatta, New South Wales, Australia, 2150 Brain and Mind Centre Sydney, New South Wales, Australia, 2050 Australia, Victoria Calvary Health Care Bethlehem Caulfield South, Victoria, Australia, 3162 收起 <<
NCT00085943 HIV Infection ... 展开 >> Infection, Human Immunodeficiency Virus 收起 << Phase 3 Completed - -
NCT00005017 HIV Infections Phase 4 Unknown - United States, North Carolina ... 展开 >> Jaime Hernandez Research Triangle Park, North Carolina, United States, 27709 收起 <<

Abacavir 参考文献

[1]Carlini F, et al. The reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines. PLoS One. 2010 Dec 3;5(12):e14221.

[2]Collado-Diaz V, et al. Abacavir Induces Arterial Thrombosis in a Murine Model. J Infect Dis. 2018 Jun 20;218(2):228-233.

[3]Gringmuth M, et al. Enhanced Survival of High-Risk Medulloblastoma-Bearing Mice after Multimodal Treatment with Radiotherapy, Decitabine, and Abacavir. Int J Mol Sci. 2022 Mar 30;23(7):3815.

Abacavir 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.49mL

0.70mL

0.35mL

17.46mL

3.49mL

1.75mL

34.92mL

6.98mL

3.49mL

Abacavir 技术信息

CAS号136470-78-5
分子式C14H18N6O
分子量 286.332
别名 1592U89
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature

溶解度

DMSO: 105 mg/mL(366.71 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 2 mg/mL(6.98 mM),配合低频超声助溶

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