产品说明书

Abacavir

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Chemical Structure| 136470-78-5 同义名 : 1592U89
CAS号 : 136470-78-5
货号 : A310646
分子式 : C14H18N6O
纯度 : 98%
分子量 : 286.332
MDL号 : MFCD00903850
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(366.71 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 2 mg/mL(6.98 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Abacavir is a competitive nucleoside reverse transcriptase inhibitor with oral activity. It inhibits HIV replication and displays anticancer potential in prostate cancer cell lines. Additionally, Abacavir can cross the blood-brain barrier and inhibit telomerase activity[1].[2].[3].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02868580 Amyotrophic Lateral Sclerosis Phase 2 Active, not recruiting June 2018 Australia, New South Wales ... 展开 >> Macquarie Neurology North Ryde, New South Wales, Australia, 2109 Westmead Hospital Parramatta, New South Wales, Australia, 2150 Brain and Mind Centre Sydney, New South Wales, Australia, 2050 Australia, Victoria Calvary Health Care Bethlehem Caulfield South, Victoria, Australia, 3162 收起 <<
NCT00085943 HIV Infection ... 展开 >> Infection, Human Immunodeficiency Virus 收起 << Phase 3 Completed - -
NCT00005017 HIV Infections Phase 4 Unknown - United States, North Carolina ... 展开 >> Jaime Hernandez Research Triangle Park, North Carolina, United States, 27709 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.49mL

0.70mL

0.35mL

17.46mL

3.49mL

1.75mL

34.92mL

6.98mL

3.49mL
参考文献

[1]Carlini F, et al. The reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines. PLoS One. 2010 Dec 3;5(12):e14221.

[2]Collado-Diaz V, et al. Abacavir Induces Arterial Thrombosis in a Murine Model. J Infect Dis. 2018 Jun 20;218(2):228-233.

[3]Gringmuth M, et al. Enhanced Survival of High-Risk Medulloblastoma-Bearing Mice after Multimodal Treatment with Radiotherapy, Decitabine, and Abacavir. Int J Mol Sci. 2022 Mar 30;23(7):3815.