4-Biphenylacetic acid is used in the synthesis of gastrosparing non-steroidal antiinflammatory drug as a potential non-steroidal antiinflammatory agent.
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4-biphenylacetic acid (BPAA) is a potential non-steroidal anti-inflammatory agent and forms solid inclusion complex with β-cyclodextrin. Topically applied, BPAA inhibited arachidonic acid, but not prostaglandin E-induced increases in rabbit intraocular pressure (IOP). BPAA inhibited the IOP response to alkali burn and altered IOP changes following paracentesis. In vitro, BPAA inhibited prostaglandin production from arachidonic acid in cell-free preparations of rabbit uvea[1].
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