4-Biphenylacetic Acid

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Chemical Structure| 5728-52-9 同义名 : Felbinac
CAS号 : 5728-52-9
货号 : A410938
分子式 : C14H12O2
纯度 : 98%
分子量 : 212.244
MDL号 : MFCD00004351
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(494.71 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 4-biphenylacetic acid (BPAA) is a potential non-steroidal anti-inflammatory agent and forms solid inclusion complex with β-cyclodextrin. Topically applied, BPAA inhibited arachidonic acid, but not prostaglandin E-induced increases in rabbit intraocular pressure (IOP). BPAA inhibited the IOP response to alkali burn and altered IOP changes following paracentesis. In vitro, BPAA inhibited prostaglandin production from arachidonic acid in cell-free preparations of rabbit uvea[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.71mL

0.94mL

0.47mL

23.56mL

4.71mL

2.36mL

47.12mL

9.42mL

4.71mL
参考文献

[1]Tolman EL, Partridge R, Myers TO, Birnbaum JE. Inhibition of prostaglandin-mediated ocular inflammatory responses by 4-biphenylacetic acid. Invest Ophthalmol. 1976 Dec;15(12):1005-8