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3-(2,4-Dihydroxyphenyl)propanoic acid
3-(2,4-Dihydroxyphenyl)propanoic acid
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货号：A100991
2,4-Dihydroxyhydrocinnamic Acid shows tyrosinase inhibition activity when mixed with l-ascorbic acid, it is a natural product isolated and purified from the herbs of Juniperus formosana.
3-(2,4-Dihydroxyphenyl)propanoic acid 化学结构
3-(2,4-Dihydroxyphenyl)propanoic acid 3D分子结构
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3-(2,4-Dihydroxyphenyl)propanoic acid 纯度/质量文件 产品仅供科研
货号：A100991
标准纯度：
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3-(2,4-Dihydroxyphenyl)propanoic acid 质控信息
Hexylresorcinol
+++
diphenolase, IC50: 0.85 μM
++
monophenolase, IC50: 1.24 μM
+++
monophenolase, IC50: 0.85 μM
diphenolase, IC50: 0.85 μM
99%+
Aloin
✔
98%
Arbutin
+
tyrosinase, IC50: 1.09 mM
98%
Monobenzone
✔
98%
Deoxyarbutin
++++
98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
3-(2,4-Dihydroxyphenyl)propanoic acid 生物活性
描述
Syn-2,3-dihydroxy-3 - (3,4-dihydroxyphenyl) propionic acid (m-DGA) is a synthetic derivative of chemical poly [3 - (3,4-dihydroxyphenyl) glyceric acid] (p-DGA). Both p-DGA and m-DGA inhibited the growth and induced death of prostate cancer cells, caused G1 phase arrest of PCa cells by regulating the expression of cell cycle regulators. Moreover, m-DGA (50 and 100 µg/mL) decreased 22Rv1 cell growth by 12–34% and 43–61% after 24 and 48h of treatment[3]
3-(2,4-Dihydroxyphenyl)propanoic acid 参考文献
[1] Chen X, Haniu A, et al. The evaluation of the synergistic effect of 3-(2,4-dihydroxyphenyl)propionic acid and l-ascorbic acid on tyrosinase inhibition. Z Naturforsch C. 2017 Mar 1;72(3-4):119-121.
[2] Dann O, Volz G. A new synthesis of psoralene [(author's transl)] . Arch Pharm (Weinheim). 1975 Feb;308(2):121-30. German.
[3] Shrotriya S, Gagan D, Ramasamy K, Raina K, Barbakadze V, Merlani M, Gogilashvili L, Amiranashvili L, Mulkijanyan K, Papadopoulos K, Agarwal C, Agarwal R. Poly[3-(3, 4-dihydroxyphenyl) glyceric acid] from Comfrey exerts anti-cancer efficacy against human prostate cancer via targeting androgen receptor, cell cycle arrest and apoptosis. Carcinogenesis. 2012 Aug;33(8):1572-80. doi: 10.1093/carcin/bgs202. Epub 2012 Jun 12. PMID: 22693258; PMCID: PMC3499058.
3-(2,4-Dihydroxyphenyl)propanoic acid 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
5.49mL
1.10mL
0.55mL
27.45mL
5.49mL
2.74mL
54.89mL
10.98mL
5.49mL
3-(2,4-Dihydroxyphenyl)propanoic acid 技术信息
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