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3-(2,4-Dihydroxyphenyl)propanoic acid

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Chemical Structure| 5631-68-5 同义名 : -
CAS号 : 5631-68-5
货号 : A100991
分子式 : C9H10O4
纯度 : 97%
分子量 : 182.173
MDL号 : MFCD00143017
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(1372.32 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Syn-2,3-dihydroxy-3 - (3,4-dihydroxyphenyl) propionic acid (m-DGA) is a synthetic derivative of chemical poly [3 - (3,4-dihydroxyphenyl) glyceric acid] (p-DGA). Both p-DGA and m-DGA inhibited the growth and induced death of prostate cancer cells, caused G1 phase arrest of PCa cells by regulating the expression of cell cycle regulators. Moreover, m-DGA (50 and 100 µg/mL) decreased 22Rv1 cell growth by 12–34% and 43–61% after 24 and 48h of treatment[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.49mL

1.10mL

0.55mL

27.45mL

5.49mL

2.74mL

54.89mL

10.98mL

5.49mL
参考文献

[1]Chen X, Haniu A, et al. The evaluation of the synergistic effect of 3-(2,4-dihydroxyphenyl)propionic acid and l-ascorbic acid on tyrosinase inhibition. Z Naturforsch C. 2017 Mar 1;72(3-4):119-121.

[2]Dann O, Volz G. A new synthesis of psoralene [(author's transl)] . Arch Pharm (Weinheim). 1975 Feb;308(2):121-30. German.

[3]Shrotriya S, Gagan D, Ramasamy K, Raina K, Barbakadze V, Merlani M, Gogilashvili L, Amiranashvili L, Mulkijanyan K, Papadopoulos K, Agarwal C, Agarwal R. Poly[3-(3, 4-dihydroxyphenyl) glyceric acid] from Comfrey exerts anti-cancer efficacy against human prostate cancer via targeting androgen receptor, cell cycle arrest and apoptosis. Carcinogenesis. 2012 Aug;33(8):1572-80. doi: 10.1093/carcin/bgs202. Epub 2012 Jun 12. PMID: 22693258; PMCID: PMC3499058.