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/ 27-Hydroxycholesterol

27-羟基胆固醇 /27-Hydroxycholesterol {[allProObj[0].p_purity_real_show]}

货号：A127551 同义名： 5,25R-胆甾烯-3BETA,26-二醇 / 27-OHC;(25R)-26-hydroxy Cholesterol

27-Hydroxycholesterol is an endogenous oxysterol with multiple biological functions, including activity as a selective estrogen receptor modulator (SERM) (a mixed, tissue-specific agonist-antagonist of the estrogen receptor (ER)) and as an agonist of the liver X receptor (LXR). It is a metabolite of cholesterol that is produced by the enzyme CYP27A1.

27-Hydroxycholesterol 化学结构 CAS号：20380-11-4
27-Hydroxycholesterol 化学结构
CAS号：20380-11-4
27-Hydroxycholesterol 3D分子结构
CAS号：20380-11-4
27-Hydroxycholesterol 化学结构 CAS号：20380-11-4
27-Hydroxycholesterol 3D分子结构 CAS号：20380-11-4
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27-Hydroxycholesterol 纯度/质量文件 产品仅供科研

货号：A127551 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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27-Hydroxycholesterol 生物活性

描述 27-Hydroxycholesterol is an endogenous oxysterol with multiple biological functions, including activity as a selective estrogen receptor modulator (SERM) (a mixed, tissue-specific agonist-antagonist of the estrogen receptor (ER)) and as an agonist of the liver X receptor (LXR). It is a metabolite of cholesterol that is produced by the enzyme CYP27A1.

27-Hydroxycholesterol 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03525184 Sleep Restriction Not Applicable Recruiting December 2019 United States, Massachusetts ... 展开 >> U.S. Army Research Institute of Environmental Medicine Recruiting Natick, Massachusetts, United States, 01760 Contact: Tracey J Smith, PhD    508-233-4868    tracey.smith10.civ@mail.mil 收起 <<
NCT02259153 Lipid Metabolism Disorders ... 展开 >> Sterols Diet, High-Fat Cholesterol Fatty Acids Hyperlipidemias 收起 << Not Applicable Completed - -
NCT01180361 - Recruiting December 2018 United States, New York ... 展开 >> Winthrop University Hospital Recruiting Mineola, New York, United States, 11501 Contact: Steven Carsons, MD    516-663-4751    SCarsons@winthrop.org    Principal Investigator: Allison B Reiss, MD          Sub-Investigator: Steven Carsons, MD 收起 <<

27-Hydroxycholesterol 参考文献

[1]Alfaqih MA, Nelson ER, et al. CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer. Cancer Res. 2017 Apr 1;77(7):1662-1673.

[2]Cedo L, Garcia-Leon A, et al. ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer. Sci Rep. 2016 Nov 3;6:36387.

27-Hydroxycholesterol 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.48mL

0.50mL

0.25mL

12.42mL

2.48mL

1.24mL

24.84mL

4.97mL

2.48mL

27-Hydroxycholesterol 技术信息

CAS号20380-11-4
分子式C27H46O2
分子量 402.653
别名 5,25R-胆甾烯-3BETA,26-二醇 ;27-OHC;(25R)-26-hydroxy Cholesterol;27-Hydroxycholesterol, 27-HC.;25(R)-27-hydroxy Cholesterol
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Store in freezer, under -20°C
溶解度

DMSO: 1 mg/mL(2.48 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 15 mg/mL(37.25 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方

Tags: 27-Hydroxycholesterol | 20380-11-4 | 27-OHC | Estrogen Receptor/ERR | LXR Agonist | Vitamin D Related/Nuclear Receptor | Metabolic Enzyme/Protease | Estrogen Receptor/ERR | LXR | Endogenous Metabolite | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | 27-Hydroxycholesterol 纯度/质量文件 | 27-Hydroxycholesterol 生物活性 | 27-Hydroxycholesterol 临床数据 | 27-Hydroxycholesterol 参考文献 | 27-Hydroxycholesterol 实验方案 | 27-Hydroxycholesterol 技术信息

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