生物活性 | |||
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描述 | 27-Hydroxycholesterol is an endogenous oxysterol with multiple biological functions, including activity as a selective estrogen receptor modulator (SERM) (a mixed, tissue-specific agonist-antagonist of the estrogen receptor (ER)) and as an agonist of the liver X receptor (LXR). It is a metabolite of cholesterol that is produced by the enzyme CYP27A1. |
临床研究 | |||||
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NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT03525184 | Sleep Restriction | Not Applicable | Recruiting | December 2019 | United States, Massachusetts ... 展开 >> U.S. Army Research Institute of Environmental Medicine Recruiting Natick, Massachusetts, United States, 01760 Contact: Tracey J Smith, PhD 508-233-4868 tracey.smith10.civ@mail.mil 收起 << |
NCT02259153 | Lipid Metabolism Disorders ... 展开 >> Sterols Diet, High-Fat Cholesterol Fatty Acids Hyperlipidemias 收起 << | Not Applicable | Completed | - | - |
NCT01180361 | - | Recruiting | December 2018 | United States, New York ... 展开 >> Winthrop University Hospital Recruiting Mineola, New York, United States, 11501 Contact: Steven Carsons, MD 516-663-4751 SCarsons@winthrop.org Principal Investigator: Allison B Reiss, MD Sub-Investigator: Steven Carsons, MD 收起 << |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.48mL 0.50mL 0.25mL |
12.42mL 2.48mL 1.24mL |
24.84mL 4.97mL 2.48mL |
参考文献 |
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