27-Hydroxycholesterol

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Chemical Structure| 20380-11-4 同义名 : 5,25R-胆甾烯-3BETA,26-二醇 ;27-OHC;(25R)-26-hydroxy Cholesterol;27-Hydroxycholesterol, 27-HC.;25(R)-27-hydroxy Cholesterol
CAS号 : 20380-11-4
货号 : A127551
分子式 : C27H46O2
纯度 : 98%
分子量 : 402.653
MDL号 : MFCD00272990
存储条件:

Pure form Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 1 mg/mL(2.48 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

无水乙醇: 15 mg/mL(37.25 mM),配合低频超声助溶,注意:无水乙醇开封后,易挥发,也会吸收空气中的水分,导致溶解能力下降,请避免使用开封较久的乙醇

动物实验配方:
生物活性
描述 27-Hydroxycholesterol is an endogenous oxysterol with multiple biological functions, including activity as a selective estrogen receptor modulator (SERM) (a mixed, tissue-specific agonist-antagonist of the estrogen receptor (ER)) and as an agonist of the liver X receptor (LXR). It is a metabolite of cholesterol that is produced by the enzyme CYP27A1.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03525184 Sleep Restriction Not Applicable Recruiting December 2019 United States, Massachusetts ... 展开 >> U.S. Army Research Institute of Environmental Medicine Recruiting Natick, Massachusetts, United States, 01760 Contact: Tracey J Smith, PhD    508-233-4868    tracey.smith10.civ@mail.mil 收起 <<
NCT02259153 Lipid Metabolism Disorders ... 展开 >> Sterols Diet, High-Fat Cholesterol Fatty Acids Hyperlipidemias 收起 << Not Applicable Completed - -
NCT01180361 - Recruiting December 2018 United States, New York ... 展开 >> Winthrop University Hospital Recruiting Mineola, New York, United States, 11501 Contact: Steven Carsons, MD    516-663-4751    SCarsons@winthrop.org    Principal Investigator: Allison B Reiss, MD          Sub-Investigator: Steven Carsons, MD 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.48mL

0.50mL

0.25mL

12.42mL

2.48mL

1.24mL

24.84mL

4.97mL

2.48mL

参考文献

[1]Alfaqih MA, Nelson ER, et al. CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer. Cancer Res. 2017 Apr 1;77(7):1662-1673.

[2]Cedo L, Garcia-Leon A, et al. ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer. Sci Rep. 2016 Nov 3;6:36387.