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(-)-表没食子儿茶素 /(-)-Epigallocatechin {[allProObj[0].p_purity_real_show]}

货号:A187930 同义名: (-)-表没食子儿茶素 / L-Epigallocatechin;(−)-EGC Ambeed 开学季,买赠积分,赢豪礼

(-)-Epigallocatechin is a plant secondary metabolite abundant in green tea, it can prevent conversion of unfolded native polypeptides to amyloid fibrils.

(-)-Epigallocatechin 化学结构 CAS号:970-74-1
(-)-Epigallocatechin 化学结构
CAS号:970-74-1
(-)-Epigallocatechin 3D分子结构
CAS号:970-74-1
(-)-Epigallocatechin 化学结构 CAS号:970-74-1
(-)-Epigallocatechin 3D分子结构 CAS号:970-74-1
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(-)-Epigallocatechin 纯度/质量文件 产品仅供科研

货号:A187930 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 Telomerase 其他靶点 纯度
4',7-Dimethoxyisoflavone {[allProObj[0].p_purity_real_show]}
BIBR 1532 +++

Telomerase, IC50: 100 nM

{[allProObj[0].p_purity_real_show]}
Costunolide ++

Telomerase (MCF-7), IC50: 90 μM

Telomerase (MDA-MB-231), IC50: 65 μM

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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

(-)-Epigallocatechin 生物活性

描述 (-)-Epigallocatechin (EGC) is a potent inhibitor of amyloidogenic cystatin I66Q amyloid fibril formation in vitro. (-)-Epigallocatechin (EGC) is the most abundant flavonoid in green tea, can bind to unfolded native polypeptides and prevent conversion to amyloid fibrils[3]. The enzyme inhibition study result indicated that epigallocatechin gallate possess strong inhibitory activity on ADA(Adenosine deaminase) [4]. Combined curcumin and EGCG (epigallocatechin gallate) treatment reduced the cancer stem-like Cluster of differentiation 44 (CD44)-positive cell population. Curcumin and EGCG function as antitumor agents for suppressing breast CSCs (cancer stem cell) [5]. In addition, EGCG (Epigallocatechin-3-gallate) exhibited a MIC and MBC of 5 μg/mL and 20 μg/mL respectively and effectively eradicated E. faecalis biofilms. EGCG induced the formation of hydroxyl radicals in E. faecalis. The antimicrobial action of EGCG on E. faecalis occurred through the generation of hydroxyl radical[6].

(-)-Epigallocatechin 参考文献

[1]Chung SS, et al. Curcumin and Epigallocatechin Gallate Inhibit the Cancer Stem Cell Phenotype via Down-regulation of STAT3-NFκB Signaling. Anticancer Res. 2015 Jan;35(1):39-46.

[2]Wang N, He J, et al. (-)-Epigallocatechin-3-gallate Inhibits Fibrillogenesis of Chicken Cystatin. J Agric Food Chem. 2015 Jan 26

[3]Wang N, He J, Chang AK, et al. (-)-epigallocatechin-3-gallate inhibits fibrillogenesis of chicken cystatin. J Agric Food Chem. 2015;63(5):1347-1351

[4]K G A, C S S, J A, C S. Biochemical and computational insights of adenosine deaminase inhibition by Epigallocatechin gallate. Comput Biol Chem. 2019;83:107111

[5]Chung SS, Vadgama JV. Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3-NFκB signaling. Anticancer Res. 2015;35(1):39-46

[6]Lee P, Tan KS. Effects of Epigallocatechin gallate against Enterococcus faecalis biofilm and virulence. Arch Oral Biol. 2015;60(3):393-399

(-)-Epigallocatechin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.27mL

0.65mL

0.33mL

16.33mL

3.27mL

1.63mL

32.65mL

6.53mL

3.27mL

(-)-Epigallocatechin 技术信息

CAS号970-74-1
分子式C15H14O7
分子量 306.267
别名 (-)-表没食子儿茶素 ;L-Epigallocatechin;(−)-EGC;()EGC;NSC 674039;(−)-Epigallocatechin;Epigallocatechin
运输蓝冰
存储条件

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 65 mg/mL(212.23 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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