产品说明书
(-)-Epigallocatechin
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同义名 : | (-)-表没食子儿茶素 ;L-Epigallocatechin;(−)-EGC;()EGC;NSC 674039;(−)-Epigallocatechin;Epigallocatechin |
| CAS号 : | 970-74-1 | |
| 货号 : | A187930 | |
| 分子式 : | C15H14O7 | |
| 纯度 : | 98% | |
| 分子量 : | 306.267 | |
| MDL号 : | MFCD00075939 | |
| 存储条件： |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 65 mg/mL(212.23 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | (-)-Epigallocatechin (EGC) is a potent inhibitor of amyloidogenic cystatin I66Q amyloid fibril formation in vitro. (-)-Epigallocatechin (EGC) is the most abundant flavonoid in green tea, can bind to unfolded native polypeptides and prevent conversion to amyloid fibrils[3]. The enzyme inhibition study result indicated that epigallocatechin gallate possess strong inhibitory activity on ADA(Adenosine deaminase) [4]. Combined curcumin and EGCG (epigallocatechin gallate) treatment reduced the cancer stem-like Cluster of differentiation 44 (CD44)-positive cell population. Curcumin and EGCG function as antitumor agents for suppressing breast CSCs (cancer stem cell) [5]. In addition, EGCG (Epigallocatechin-3-gallate) exhibited a MIC and MBC of 5 μg/mL and 20 μg/mL respectively and effectively eradicated E. faecalis biofilms. EGCG induced the formation of hydroxyl radicals in E. faecalis. The antimicrobial action of EGCG on E. faecalis occurred through the generation of hydroxyl radical[6]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.27mL 0.65mL 0.33mL |
16.33mL 3.27mL 1.63mL |
32.65mL 6.53mL 3.27mL |
| 参考文献 |
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