α-Cyano-4-hydroxycinnamic acid is a potent, non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits the mitochondrial pyruvate transporter with a Ki value of 6.3 μM. α-Cyano-4-hydroxycinnamic acid may be used as an inhibitor of the mitochondrial pyruvate transporter. Hydroxycinnamic acid can be used as a matrix to facilitate peptide ionization in MALDI-TOF mass spectrometry applications[1][2].α-Cyano-4-hydroxycinnamic acid inhibits the transport of monocarboxylates such as lactate and pyruvate[2].1 mM concentration of α-Cyano-4-hydroxycinnamic acid has a significant inhibitory effect on branching morphogenesis and reduces epithelial perimeter and area of lung explants in a dose-dependent manner[2].At a concentration of 100 μM, α-Cyano-4-hydroxycinnamic acid rapidly and almost completely inhibits O2 uptake during pyruvate oxidation in rat heart mitochondria. Inhibition was detected at inhibitor concentrations as low as 1 μM, although time was required for inhibition to occur at this concentration[1].
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