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α-Cyano-4-hydroxycinnamic acid

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Chemical Structure| 28166-41-8 同义名 : 2-氰基-4-羟基 ;α-Cyano-4-hydroxycinnamate;CHC;α-CHCA, α-Cyano-4-hydroxycinnamic acid, CHC;NSC 173138;α-CHCA
CAS号 : 28166-41-8
货号 : A722869
分子式 : C10H7NO3
纯度 : 98%
分子量 : 189.17
MDL号 : MFCD00004204
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(1321.58 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 α-Cyano-4-hydroxycinnamic acid is a potent, non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits the mitochondrial pyruvate transporter with a Ki value of 6.3 μM. α-Cyano-4-hydroxycinnamic acid may be used as an inhibitor of the mitochondrial pyruvate transporter. Hydroxycinnamic acid can be used as a matrix to facilitate peptide ionization in MALDI-TOF mass spectrometry applications[1][2].α-Cyano-4-hydroxycinnamic acid inhibits the transport of monocarboxylates such as lactate and pyruvate[2].1 mM concentration of α-Cyano-4-hydroxycinnamic acid has a significant inhibitory effect on branching morphogenesis and reduces epithelial perimeter and area of lung explants in a dose-dependent manner[2].At a concentration of 100 μM, α-Cyano-4-hydroxycinnamic acid rapidly and almost completely inhibits O2 uptake during pyruvate oxidation in rat heart mitochondria. Inhibition was detected at inhibitor concentrations as low as 1 μM, although time was required for inhibition to occur at this concentration[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.29mL

1.06mL

0.53mL

26.43mL

5.29mL

2.64mL

52.86mL

10.57mL

5.29mL
参考文献

[1]A P Halestrap, et al. The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors. Biochem J. 1975 Apr; 148(1): 85-96.

[2]Sara Granja, et al. The Monocarboxylate Transporter Inhibitor α-cyano-4-hydroxycinnamic Acid Disrupts Rat Lung Branching. Cell Physiol Biochem. 2013;32(6):1845-56.