AZ 191 is a potent and selective DYRK1B inhibitor with IC50 of 17 nM in a cell-free assay, about 5- and 110-fold selectivity over DYRK1A and DYRK2, respectively.

Harmine是一种天然的双特异性酪氨酸磷酸化调节激酶（DYRK）抑制剂，具有抗癌和抗炎活性。它对5-HT2A血清素受体具有高亲和力，Ki值为397 nM。