SB 431542 是一种用于 SMAD 信号传导的 TGF-β 受体激酶抑制剂 (TRKI)。

LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM in a cell-free assay.

LY2109761是一种口服活性和选择性的TGF-β I/II型受体抑制剂，其Ki值分别为38 nM和300 nM。

SB-525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3 nM, is 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6.

SB-505124是一种选择性 TGF-β 受体 I 型受体 (ALK4、ALK5、ALK7) 抑制剂，对 ALK4 和 ALK5 的 IC50 值分别为 129 nM 和 47 nM，不抑制 ALK1、2、3 或 6。

GW788388是一种有效且选择性的ALK5抑制剂，IC50为18 nM，同时也抑制TGF-β II型受体和activin II型受体活性，而对BMP II型受体无影响。

LY364947（HTS466284）是一种有效的ATP竞争性TGFβR-I抑制剂，IC50值为59 nM，并对TGFβR-II具有7倍的选择性。

RepSox (E-616452)是一种有效且选择性的TGF-β-RI/ALK5抑制剂。

SD-208 is a potent, orally active ATP-competitive transforming growth factor-β receptor 1 (TGF-βRI) inhibitor (IC50= 49 nM) and displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common kinases respectively.

EW-7197 is a selective inhibitor of TGF-β receptor ALK4 and ALK5 with IC50s of 13 nM and 11 nM.

LDN-212854 is an inhibitor of BMP and can inhibit ALK2 with IC50 of 1.3 nM. It is used to prevent heterotopic ossification.