TAK-981 is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities.

Ginkgolic Acid是从银杏叶（Ginkgo biloba L.）中分离纯化的天然产物，作为一种有效的SUMO化抑制剂，也可抑制组蛋白乙酰化转移酶（HAT）。 。

COH000 is an irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) with IC50 of 0.2 μM for SUMOylation in vitro.