β-Sitosterol, a natural product isolated and purified from the herbs of Anemone cathayensis Kitag., is one of several phytosterols (plant sterols) with chemical structures similar to that of cholesterol.
β-Sitosterol (beta-sitosterol, BS), a plant derived nutrient with anticancer properties against breast cancer, prostate cancer, colon cancer, lung cancer, stomach cancer, ovarian cancer, and leukemia[3]. β-sitosterol significantly ameliorated HFWD(high-fat western-style diet)-induced fatty liver and metabolic abnormalities, including elevated levels of hepatic total lipids, triacylglycerols, cholesterol and liver histopathology. It decreased the levels of intestinal bile acids, accompanied by markedly increased fecal lipid levels.β-Sitosterol was less effective in affecting most of these parameters[4]. β-sitosterol protected against in vitro H/R(hypoxia/reoxygenation)-induced cardiomyocyte injury and in vivo myocardial I/R (ischemia/reperfusion) injury[5]. The combination of β-sitosterol and naringenin exerted a synergistic effect on wound closure without decreasing the viability of fibroblasts, increased antioxidant defense mechanism and decreased IL-β[6].
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