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β-Sitosterol

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Chemical Structure| 83-46-5 同义名 : 谷甾醇 ;β-Sitosterol;22,23-Dihydrostigmasterol;(-)-beta-Sitosterol, 22,23-Dihydrostigmasterol, 24-alpha-Ethylcholesterol, AI3-26020, alpha-Dihydrofucosterol, Angelicin, Azuprostat, beta-Sitosterol, CCRIS 5529, Cinchol, Cupreol, Harzol, Nimbosterol, Prostasal, Quebrachol, Rhamnol, Triastonal;SKF 14463;Rhamnol;NSC 8096;NSC 49083;NSC 18173;Cupreol;Betaprost;Azuprostat;24α-ethyl Cholesterol
CAS号 : 83-46-5
货号 : A401976
分子式 : C29H50O
纯度 : 75+%
分子量 : 414.71
MDL号 : MFCD00003631
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

无水乙醇: 3.5 mg/mL(8.44 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方：
生物活性
描述 β-Sitosterol (beta-sitosterol, BS), a plant derived nutrient with anticancer properties against breast cancer, prostate cancer, colon cancer, lung cancer, stomach cancer, ovarian cancer, and leukemia[3]. β-sitosterol significantly ameliorated HFWD(high-fat western-style diet)-induced fatty liver and metabolic abnormalities, including elevated levels of hepatic total lipids, triacylglycerols, cholesterol and liver histopathology. It decreased the levels of intestinal bile acids, accompanied by markedly increased fecal lipid levels.β-Sitosterol was less effective in affecting most of these parameters[4]. β-sitosterol protected against in vitro H/R(hypoxia/reoxygenation)-induced cardiomyocyte injury and in vivo myocardial I/R (ischemia/reperfusion) injury[5]. The combination of β-sitosterol and naringenin exerted a synergistic effect on wound closure without decreasing the viability of fibroblasts, increased antioxidant defense mechanism and decreased IL-β[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.41mL

0.48mL

0.24mL

12.06mL

2.41mL

1.21mL

24.11mL

4.82mL

2.41mL
参考文献

[1]Mannock DA, Benesch MG, et al. A comparative calorimetric and spectroscopic study of the effects of cholesterol and of the plant sterols β-sitosterol and stigmasterol on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes. Biochim Biophys Acta. 2015 Aug;1848(8):1629-38.

[2]de Mello VD, Lindstrom J, et al. Markers of cholesterol metabolism as biomarkers in predicting diabetes in the Finnish Diabetes Prevention Study. Nutr Metab Cardiovasc Dis. 2015 Jul;25(7):635-42.

[3]Bin Sayeed MS, Ameen SS. Beta-Sitosterol: A Promising but Orphan Nutraceutical to Fight Against Cancer. Nutr Cancer. 2015;67(8):1214-20

[4]Feng S, Dai Z, Liu AB, Huang J, Narsipur N, Guo G, Kong B, Reuhl K, Lu W, Luo Z, Yang CS. Intake of stigmasterol and β-sitosterol alters lipid metabolism and alleviates NAFLD in mice fed a high-fat western-style diet. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct;1863(10):1274-1284

[5]Lin F, Xu L, Huang M, Deng B, Zhang W, Zeng Z, Yinzhi S. β-Sitosterol Protects against Myocardial Ischemia/Reperfusion Injury via Targeting PPARγ/NF-κB Signalling. Evid Based Complement Alternat Med. 2020 Mar 28;2020:2679409

[6]Abbas MM, Al-Rawi N, Abbas MA, Al-Khateeb I. Naringenin potentiated β-sitosterol healing effect on the scratch wound assay. Res Pharm Sci. 2019 Dec 11;14(6):566-573