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/ β-Cholestanol

二氢胆固醇 /β-Cholestanol {[allProObj[0].p_purity_real_show]}

货号：A744586 同义名： 二氢胆甾醇 / 5α-Cholestanol;Dihydrocholesterol

Dihydrocholesterol is a cholesterol derivative found in human feces, gallstones, eggs and other biological matter, it could reduce plasma cholesterol by inhibiting the cholesterol absorption and increasing the fecal sterol excretion.

β-Cholestanol 化学结构 CAS号：80-97-7
β-Cholestanol 化学结构
CAS号：80-97-7
β-Cholestanol 3D分子结构
CAS号：80-97-7
β-Cholestanol 化学结构 CAS号：80-97-7
β-Cholestanol 3D分子结构 CAS号：80-97-7
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β-Cholestanol 纯度/质量文件 产品仅供科研

货号：A744586 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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β-Cholestanol 生物活性

描述 Dihydrocholesterol, also known as cholestanol or zymostanol, belongs to the class of organic compounds known as cholesterols and derivatives. Rabbits fed a diet containing 0.75% dihydrocholesterol for 7 days develop bile acid allodeoxycholic (ADCA) and deoxycholic acid (DCA) stones in the gallbladder[1]. Whereas dihydrocholesterol exhibits a condensing power that is equivalent to that of cholesterol, the action of coprostanol is significantly weaker[2]. Proliferation of the epithelial cells of the gall bladder during the initial stages of experimental cholelithiasis has been studied by autoradiography. Rabbits taking a diet with 1% dihydrocholesterol added showed a rise in labelling index from 1.5%-19% by three days[3]. The auxotroph grows normally on desmosterol and trans-22-dehydrocholesterol and at reduced rates on dihydrocholesterol, campesterol, and 22,23-dihydrobrassicasterol. In cells grown with dihydrocholesterol, a marked increase in desaturation and elongation of fatty acids is noted[4].

β-Cholestanol 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01131832 Hyperlipidemia Phase 4 Completed - United States, Maryland ... 展开 >> USDA-ARS, Beltsville Human Nutrition Research Center Beltsville, Maryland, United States, 20705 Canada, Manitoba Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba Winnipeg, Manitoba, Canada, R3T 6C5 收起 <<
NCT00867165 Primary Hypercholesterolemia Phase 3 Completed - -
NCT01902394 Digestive Health and Immune Fu... 展开 >>nction 收起 << Not Applicable Completed - United States, Massachusetts ... 展开 >> HNCRA at Tufts University Boston, Massachusetts, United States, 02111 收起 <<

β-Cholestanol 参考文献

[1]Lee SP, Scott AJ. Dihydrocholesterol-induced gallstones in the rabbit: evidence that bile acids cause gallbladder epithelial injury. Br J Exp Pathol. 1979 Jun;60(3):231-8

[2]Daly TA, Wang M, Regen SL. The origin of cholesterol's condensing effect. Langmuir. 2011 Mar 15;27(6):2159-61

[3]Scott AJ. Epithelial cell proliferation in diverse models of experimental cholelithiasis. Gut. 1978 Jun;19(6):558-62

[4]Rujanavech C, Silbert DF. LM cell growth and membrane lipid adaptation to sterol structure. J Biol Chem. 1986 Jun 5;261(16):7196-203

β-Cholestanol 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.57mL

0.51mL

0.26mL

12.86mL

2.57mL

1.29mL

25.73mL

5.15mL

2.57mL

β-Cholestanol 技术信息

CAS号80-97-7
分子式C27H48O
分子量 388.669
别名 二氢胆甾醇 ;5α-Cholestanol;Dihydrocholesterol;(+)-Dihydrocholesterol;Cholestanol;NSC 18188;5α-Cholestan-3β-ol
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature
溶解度

无水乙醇: 8 mg/mL(20.58 mM)，配合低频超声，并水浴加热至45℃助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方

Tags: 5α-Cholestan-3β-ol | 80-97-7 | Dihydrocholesterol | 5α-Cholestanol | NSC 18188 | NSC18188 | NSC 18188 | NSC-18188 | Metabolic Enzyme/Protease | Endogenous Metabolite | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | β-Cholestanol 纯度/质量文件 | β-Cholestanol 生物活性 | β-Cholestanol 临床数据 | β-Cholestanol 参考文献 | β-Cholestanol 实验方案 | β-Cholestanol 技术信息

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