产品说明书
β-Cholestanol
 |
同义名 : | 二氢胆甾醇 ;5α-Cholestanol;Dihydrocholesterol;(+)-Dihydrocholesterol;Cholestanol;NSC 18188;5α-Cholestan-3β-ol |
| CAS号 : | 80-97-7 | |
| 货号 : | A744586 | |
| 分子式 : | C27H48O | |
| 纯度 : | 98% | |
| 分子量 : | 388.669 | |
| MDL号 : | MFCD00066413 | |
| 存储条件： |
粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
无水乙醇: 8 mg/mL(20.58 mM)，配合低频超声，并水浴加热至45℃助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Dihydrocholesterol, also known as cholestanol or zymostanol, belongs to the class of organic compounds known as cholesterols and derivatives. Rabbits fed a diet containing 0.75% dihydrocholesterol for 7 days develop bile acid allodeoxycholic (ADCA) and deoxycholic acid (DCA) stones in the gallbladder[1]. Whereas dihydrocholesterol exhibits a condensing power that is equivalent to that of cholesterol, the action of coprostanol is significantly weaker[2]. Proliferation of the epithelial cells of the gall bladder during the initial stages of experimental cholelithiasis has been studied by autoradiography. Rabbits taking a diet with 1% dihydrocholesterol added showed a rise in labelling index from 1.5%-19% by three days[3]. The auxotroph grows normally on desmosterol and trans-22-dehydrocholesterol and at reduced rates on dihydrocholesterol, campesterol, and 22,23-dihydrobrassicasterol. In cells grown with dihydrocholesterol, a marked increase in desaturation and elongation of fatty acids is noted[4]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01131832 | Hyperlipidemia | Phase 4 | Completed | - | United States, Maryland ... 展开 >> USDA-ARS, Beltsville Human Nutrition Research Center Beltsville, Maryland, United States, 20705 Canada, Manitoba Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba Winnipeg, Manitoba, Canada, R3T 6C5 收起 << |
| NCT00867165 | Primary Hypercholesterolemia | Phase 3 | Completed | - | - |
| NCT01902394 | Digestive Health and Immune Fu... 展开 >>nction 收起 << | Not Applicable | Completed | - | United States, Massachusetts ... 展开 >> HNCRA at Tufts University Boston, Massachusetts, United States, 02111 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.57mL 0.51mL 0.26mL |
12.86mL 2.57mL 1.29mL |
25.73mL 5.15mL 2.57mL |
| 参考文献 |
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