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α-Linolenic acid

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Chemical Structure| 463-40-1 同义名 : α-亚麻酸 ;Octadecatrienoic acid (all cis-9,12,15);alpha-Linolenic acid;DPN63401;C18:3 (all cis-9,12,15) Fatty acid
CAS号 : 463-40-1
货号 : A843943
分子式 : C18H30O2
纯度 : 97% GC
分子量 : 278.43
MDL号 : MFCD00065720
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(377.12 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 100 mg/mL(359.16 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方：
生物活性
靶点

  • PI3K
描述 α-Linolenic acid (ALA), isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer. α-Linolenic acid (50, 100, 250 mg/kg; for 10 days) can completely inhibit collagen- and adrenaline-induced thrombosis in mice at 250 mg/kg. α-Linolenic acid (35, 70, 175 mg/kg) suppresses A-V thrombus formation in rats (weighing at 250 ~ 300 g). α-Linolenic acid (70 or 175 mg/kg) inhibits collagen stimulated platelet aggregation in rats[3]. ALA but not LA supplementation alleviated systolic blood pressure elevation and improved ACh-induced, endothelium-dependent vasodilation in both spontaneously hypertensive rats (SHRs) and AngII-induced hypertensive mice. In primary cultured endothelial cells, ALA treatment directly inhibited SIRT3 reduction, SOD2 hyperacetylation, mitochondrial ROS overproduction and alleviated autophagic flux impairment induced by AngII plus TNFα treatment[4]. Consumption of vegetable oils rich in alpha-linolenic acid could confer important cardiovascular protection[5]. α-linolenic acid prevents ER stress-mediated apoptosis of stearic acid lipotoxicity on primary rat hepatocytes might become a target to develop new antiapoptotic compounds in nonalcoholic fatty liver disease[6]. ALA also as a potential nutraceutical to protect the brain from stroke, characterized by its pleiotropic effects in neuroprotection, vasodilation of brain arteries, and neuroplasticity[7].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00892684 Allergies Not Applicable Unknown September 2011 Sweden ... 展开 >> University Hospital Linkoeping, Sweden, 58185 收起 <<
NCT01943409 Obstruction C... 展开 >>ancer Ileus Malnutrition Surgery 收起 << Phase 4 Recruiting June 2019 Canada, Ontario ... 展开 >> University Health Network Recruiting Toronto, Ontario, Canada, M5G 2C4 Contact: Sultan Alenezi, MScAHN    +1-416-340-4413    sultan.alenezi@uhnresearch.ca    Contact: Monica L Ponta, MD    +1-416-340-4413    monica.ponta@uhnresearch.ca    Principal Investigator: Johane P Allard, MD 收起 <<
NCT02590848 Vitamin/Nutritional Deficiency... 展开 >> Neurobehavioral Manifestations 收起 << Not Applicable Active, not recruiting January 2019 Spain ... 展开 >> Fundació Centre de Recerca en Epidemiologia Ambiental Barcelona, Spain, 08003 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.59mL

0.72mL

0.36mL

17.96mL

3.59mL

1.80mL

35.92mL

7.18mL

3.59mL
参考文献

[1]Jovanovski E, Li D, et al. The effect of alpha-linolenic acid on glycemic control in individuals with type 2 diabetes: A systematic review and meta-analysis of randomized controlled clinical trials. Medicine (Baltimore). 2017 May;96(21):e6531.

[2]Marei WFA, De Bie J, et al. Alpha-linolenic acid protects the developmental capacity of bovine cumulus-oocyte complexes matured under lipotoxic conditions in vitro. Biol Reprod. 2017 May 18.

[3]Yang Q, Cao W, Zhou X, Cao W, Xie Y, Wang S. Anti-thrombotic effects of α-linolenic acid isolated from Zanthoxylum bungeanum Maxim seeds. BMC Complement Altern Med. 2014 Sep 23;14:348

[4]Li G, Wang X, Yang H, Zhang P, Wu F, Li Y, Zhou Y, Zhang X, Ma H, Zhang W, Li J. α-Linolenic acid but not linolenic acid protects against hypertension: critical role of SIRT3 and autophagic flux. Cell Death Dis. 2020 Feb 3;11(2):83

[5]Campos H, Baylin A, Willett WC. Alpha-linolenic acid and risk of nonfatal acute myocardial infarction. Circulation. 2008 Jul 22;118(4):339-45

[6]Zhang Y, Dong L, Yang X, Shi H, Zhang L. α-Linolenic acid prevents endoplasmic reticulum stress-mediated apoptosis of stearic acid lipotoxicity on primary rat hepatocytes. Lipids Health Dis. 2011 May 18;10:81

[7]Blondeau N, Lipsky RH, Bourourou M, Duncan MW, Gorelick PB, Marini AM. Alpha-linolenic acid: an omega-3 fatty acid with neuroprotective properties-ready for use in the stroke clinic? Biomed Res Int. 2015;2015:519830