diABZI STING agonist-1 3HCl is a selective STING agonist with EC50 values of 130 and 186 nM in humans and mice, respectively. diABZI STING agonist-1 3HCl is highly selective for more than 350 kinases at a concentration of 1 μM[1].
diABZI STING agonist-1 3HCl 动物研究
Animal study
Administered intravenously at a dose of 3 mg/kg, diABZI STING agonist-1 3HCl demonstrated a systemic exposure half-life of 1.4 hours and achieved systemic concentrations higher than the EC50 for mouse STING (200 ng/ml). Administered subcutaneously at a dose of 2.5 mg/kg, diABZI STING agonist-1 3HCl induced STING-dependent activation of type I interferons and pro-inflammatory cytokines in in vivo experiments. In the BALB/c mouse colorectal tumour homozygous mouse model (CT-26), diABZI STING agonist-1 3HCl, administered intravenously at a dose of 1.5 mg/kg, significantly inhibited tumour growth and significantly increased animal survival. At the end of the study on day 43, 8 out of 10 mice remained tumour free[1].
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